Ibuprofen amino acid derivatives: synthesis, docking and biological studies
Selim, A., Ewies, E., Attia, R., Shedid, S., El-Gazzar, M. (2022). Ibuprofen amino acid derivatives: synthesis, docking and biological studies. EKB Journal Management System, 65(9), 749-761. doi: 10.21608/ejchem.2022.130671.5755
AbdelHameed Selim; Ewies F. Ewies; Reem T Attia; Said M. Shedid; Mohamed A El-Gazzar. "Ibuprofen amino acid derivatives: synthesis, docking and biological studies". EKB Journal Management System, 65, 9, 2022, 749-761. doi: 10.21608/ejchem.2022.130671.5755
Selim, A., Ewies, E., Attia, R., Shedid, S., El-Gazzar, M. (2022). 'Ibuprofen amino acid derivatives: synthesis, docking and biological studies', EKB Journal Management System, 65(9), pp. 749-761. doi: 10.21608/ejchem.2022.130671.5755
Selim, A., Ewies, E., Attia, R., Shedid, S., El-Gazzar, M. Ibuprofen amino acid derivatives: synthesis, docking and biological studies. EKB Journal Management System, 2022; 65(9): 749-761. doi: 10.21608/ejchem.2022.130671.5755

Ibuprofen amino acid derivatives: synthesis, docking and biological studies

Egyptian Journal of Chemistry
Article 68, Volume 65, Issue 9, September 2022, Page 749-761  XML PDF (792.25 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2022.130671.5755
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Authors
AbdelHameed Selim email 1; Ewies F. Ewiesorcid 2; Reem T Attia3; Said M. Shedid4; Mohamed A El-Gazzar4
1Chemistry Department, Faculty of Science, Al-Azhar University (Boys' Branch), Nasr City, Cairo, Egypt
2Organometallic and Organometalloid Chemistry, Chemical Industries Research Institute, National Research Centre
3Department of Pharmacology, Toxicology and Biochemistry, Future University in Egypt, Cairo, Egypt.
4Chemistry Department, Faculty of Science, Al-Azhar University (Boys' Branch), Nasr City, Cairo, Egypt
Abstract
This work aimed to synthesize new Ibuprofen amino acid derivatives as safe non-steroidal anti-inflammatory drugs (NSAIDs). The structures of the synthesized compounds have been determined using various spectral data. For tested compounds , molecular docking was performed into the cyclooxygnase-2 (COX-2) active site. The lowest root-mean-square deviation of atomic positions (RMSD) pose has been chosen for the binding affinity discussion. Docking protocol revealed that the binding interaction increased by the presence of hydrazide fragment in the tested compounds. Passed compounds through docking profile were examined for their anti -inflammatory and analgesic activities. Using a carrageenan-induced mouse model of hind paw edoema, we investigated the potential anti-inflammatory efficacy of the synthetic compounds in comparison to their parent molecule, ibuprofen. In addition to assessing the antinociceptive and ulcerogenic properties of the synthesized compounds
Keywords
NSAIDs; Peptide candidates; Anti-inflammatory and Analgesic agents; docking
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