Possible protective effects of sulfasalazine on acetic acid-induced colitis in rats through its effect on oxidative stress and proinflammatory mediators | ||||
| Minia Journal of Medical Research | ||||
| Volume 32, Issue 4, October 2021, Page 30-37 PDF (454.45 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjmr.2021.242022 | ||||
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| Authors | ||||
| Alyaa A. Abdelmonaem1; Walaa Y. Abdelzaher1; Seham A. Abd-El Gaber2; Heba M. Hafez2 | ||||
| 1Department of Pharmacology, Faculty of Medicine, Minia University | ||||
| 2Department of Histology, Faculty of Medicine, Minia University | ||||
| Abstract | ||||
| There is no clear data addressing the role of oxidative stress and proinflammatory mediators in acetic acid (AA)-induced colitis model. This study was aimed to study the effect of sulfasalazine (SLZ) on AA-induced colitis in rats. Rats were allocated into 3 groups: group 1: control, group 2: AA group (received 1 ml 4% acetic acid transrectaly single dose at 13th day), group 3: SLZ+AA group (recieved SLZ 250 mg/kg/day orally for 14 days and 1 ml 4% acetic acid transrectaly single dose at 13th day). Rats were sacrificed after 2 weeks. The colonic oxidative damage and inflammatory effects of AA were evaluated by measuring colonic levels of malonaldehyde (MDA), total antioxidant capacity (TAC), superoxide dismutase (SOD), histamine, interleukin-1β (IL-1β), interleukin-18 (IL-18) and histopathological assessment. Colitis induced by AA revealed statistically significant improvement in rats treated with SLZ compared with AA alone group. These results suggest that SLZ can protect against AA- induced colitis. SLZ effects rely, at least partially, on its antioxidant and anti-inflammatory effects. | ||||
| Keywords | ||||
| acetic acid; colitis; sulfasalazine; oxidative stress; histamine; IL-1β; IL-18 | ||||
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