Correlation between Radiological and Total Nasal Symptom Severity Score Effect of Montelukast in Patient with Allergic Rhinitis Associated with Inferior Turbinate Hypertrophy
Awwad, A., Farag, M., El Sayed, S., Elbayoumy, F., Ibrrahim, M., El Boraey, H. (2022). Correlation between Radiological and Total Nasal Symptom Severity Score Effect of Montelukast in Patient with Allergic Rhinitis Associated with Inferior Turbinate Hypertrophy. EKB Journal Management System, 88(1), 2826-2829. doi: 10.21608/ejhm.2022.242278
Ayat A. Awwad Awwad; Mohamed Fekry Farag; Said Sharaf Mohammed Mohammed El Sayed; Fayez Mohammed Abd Elfattah Elbayoumy; Mosaad Mohmed Ibrrahim; Husseini Fathi Husseini Mohamed El Boraey. "Correlation between Radiological and Total Nasal Symptom Severity Score Effect of Montelukast in Patient with Allergic Rhinitis Associated with Inferior Turbinate Hypertrophy". EKB Journal Management System, 88, 1, 2022, 2826-2829. doi: 10.21608/ejhm.2022.242278
Awwad, A., Farag, M., El Sayed, S., Elbayoumy, F., Ibrrahim, M., El Boraey, H. (2022). 'Correlation between Radiological and Total Nasal Symptom Severity Score Effect of Montelukast in Patient with Allergic Rhinitis Associated with Inferior Turbinate Hypertrophy', EKB Journal Management System, 88(1), pp. 2826-2829. doi: 10.21608/ejhm.2022.242278
Awwad, A., Farag, M., El Sayed, S., Elbayoumy, F., Ibrrahim, M., El Boraey, H. Correlation between Radiological and Total Nasal Symptom Severity Score Effect of Montelukast in Patient with Allergic Rhinitis Associated with Inferior Turbinate Hypertrophy. EKB Journal Management System, 2022; 88(1): 2826-2829. doi: 10.21608/ejhm.2022.242278

Correlation between Radiological and Total Nasal Symptom Severity Score Effect of Montelukast in Patient with Allergic Rhinitis Associated with Inferior Turbinate Hypertrophy

The Egyptian Journal of Hospital Medicine
Article 86, Volume 88, Issue 1, July 2022, Page 2826-2829  XML PDF (712.18 K)
DOI: 10.21608/ejhm.2022.242278
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Authors
Ayat A. Awwad Awwad* 1; Mohamed Fekry Farag2; Said Sharaf Mohammed Mohammed El Sayed3; Fayez Mohammed Abd Elfattah Elbayoumy4; Mosaad Mohmed Ibrrahim5; Husseini Fathi Husseini Mohamed El Boraey6
1Departments of 1Otorhinolaryngology
22Department of Medical Physiology, Armed Force Faculty of Medicine, Cairo, Egypt
33Department of Medical Physiology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
44Anatomy & Embryology
55Medical Biochemistry, ART Unit, International Islamic Center for Population Studies & Research
66Radiodiagnosis, Faculty of Medicine, Al-Azhar University, New Damyetta, Egypt
Abstract
Background: Allergic rhinitis (AR) is immunoglobulin E (IgE)-mediated inflammation of the nasal mucosa on exposure to allergens. Hypertrophic rhinitis (HR) is a common complication for AR, and often need turbinate surgery. Montelukast was evidenced to have an effective role in treatment in AR. Objective: The aim of the current work was to correlate between radiological and total nasal symptom severity score (TNSSS) effect of montelukast in patient with allergic rhinitis associated with inferior turbinate hypertrophy. Patients and methods: This prospective comparative case control study included a total of 100 allergic patients suffering from nasal obstruction due to inferior turbinate hypertrophy (study group) and 100 non-allergic patients (control group), attending at Outpatient Clinics, ENT Department, Al-Azhar University Hospitals, Egypt. The effect Montelukast was assessed by (TNSSS), radiologically by (CT) scan. Serum levels of IgE, TGF-β and IL13 were measured. Result: Montelukast showed improvement of all nasal symptoms score with highly significant improvement TNSSS (P=0.003) and significant reduction on inferior turbinate size (p=0.001) compared to control. In addition to, significant reduction in serum levels of IgE, TGF-β and IL13. Conclusion: Montelukast could be effective alternative treatment for inferior turbinate hypertrophy.
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