Combined Albumin-Bilirubin Grade and Platelets (ALBI-PLT) Score and Albumin-Bilirubin Score (ALBI) as Simple Noninvasive Laboratory Markers for Prediction of Esophageal Varices in Cirrhotic Patients
Alegaily, H., Khalil, M., Thabet, A., Abdulaziz, B. (2022). Combined Albumin-Bilirubin Grade and Platelets (ALBI-PLT) Score and Albumin-Bilirubin Score (ALBI) as Simple Noninvasive Laboratory Markers for Prediction of Esophageal Varices in Cirrhotic Patients. EKB Journal Management System, 88(1), 2830-2837. doi: 10.21608/ejhm.2022.242279
Hatem S. Alegaily; Medhat A. Khalil; Aida Thabet; Badawy A. Abdulaziz. "Combined Albumin-Bilirubin Grade and Platelets (ALBI-PLT) Score and Albumin-Bilirubin Score (ALBI) as Simple Noninvasive Laboratory Markers for Prediction of Esophageal Varices in Cirrhotic Patients". EKB Journal Management System, 88, 1, 2022, 2830-2837. doi: 10.21608/ejhm.2022.242279
Alegaily, H., Khalil, M., Thabet, A., Abdulaziz, B. (2022). 'Combined Albumin-Bilirubin Grade and Platelets (ALBI-PLT) Score and Albumin-Bilirubin Score (ALBI) as Simple Noninvasive Laboratory Markers for Prediction of Esophageal Varices in Cirrhotic Patients', EKB Journal Management System, 88(1), pp. 2830-2837. doi: 10.21608/ejhm.2022.242279
Alegaily, H., Khalil, M., Thabet, A., Abdulaziz, B. Combined Albumin-Bilirubin Grade and Platelets (ALBI-PLT) Score and Albumin-Bilirubin Score (ALBI) as Simple Noninvasive Laboratory Markers for Prediction of Esophageal Varices in Cirrhotic Patients. EKB Journal Management System, 2022; 88(1): 2830-2837. doi: 10.21608/ejhm.2022.242279

Combined Albumin-Bilirubin Grade and Platelets (ALBI-PLT) Score and Albumin-Bilirubin Score (ALBI) as Simple Noninvasive Laboratory Markers for Prediction of Esophageal Varices in Cirrhotic Patients

The Egyptian Journal of Hospital Medicine
Article 87, Volume 88, Issue 1, July 2022, Page 2830-2837  XML PDF (397.87 K)
DOI: 10.21608/ejhm.2022.242279
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Authors
Hatem S. Alegaily1; Medhat A. Khalil2; Aida Thabet3; Badawy A. Abdulaziz* 1
1Departments of 1Hepatology, Gastroenterology and infectious Diseases
22Internal Medicine
33Clinical and Chemical Pathology, Faculty of Medicine, Benha University, Benha, Egypt
Abstract
Background: Esophageal varices (OVs) are common side effects of liver cirrhosis that can be life-threatening. Esophago-gastroduodenoscopy (EGD) is the gold standard for detecting OVs. In spite of this, it is intrusive and expensive.
Objective: The aim of the current work was to evaluate albumin-Bilirubin Score (ALBI), AST/ALT ratio, aspartate to platelet count ratio index (APRI), Child-Pugh Score, albumin-bilirubin grade, platelets (ALBI-PLT score) and platelet count/spleen diameter ratio as noninvasive laboratory markers for prediction of OVs in cirrhotic patients.
Patients and Methods: Two hundred and sixty patients with liver cirrhosis were screened for OVs.
CBC, liver and kidney profiles and abdominal ultrasonography were done, ALBI, ALBI-PLT score, AST/ALT ratio, APRI, a Child-Pugh Score and platelet count/spleen diameter ratio were measured for all patients. Also, EGDs were performed by one professional endoscopist for all patients.
Results: ALBI, ALBI-PLT, Platelet count/spleen diameter ratio and Child-Pugh Score were reliable indicators of esophageal varices. The best one was ALBI-PLT where at cut-off >2, may predict OVs with sensitivity 96.48 and specificity 87.76 (P< 0.001). Using ALBI at a cutoff >-2.6. may predict OVs with sensitivity of 83.77% and specificity of 53.26% (P = 0.001). Also, these noninvasive markers could help in detecting OV's size (P <0.001).
Conclusion: It could be concluded that the combined albumin-bilirubin and platelet grade (ALBI-PLT) and the albumin-bilirubin ratio (ALBI), Platelet count/spleen diameter ratio and Child-Pugh Score could be used as noninvasive markers for detecting esophageal varices and grading them.
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