Hepatitis C Virus Clearance with Sofosbuvir / Daclatasvir Regime Improves Oxidative Stress of Diabetic Status in HCV Patients by Regulating NF-κB / Nrf2 mRNA expression | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 65, Issue 132, December 2022, Page 1437-1447 PDF (782.21 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2022.135231.5945 | ||||
 View on SCiNiTO | ||||
| Author | ||||
Abeer Mohamed Abd El-Hameed 
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| Department of Chemistry, Faculty of Science, Taibah University, Saudi Arabia | ||||
| Abstract | ||||
| Background: HCV eradication improves both hepatic and non-hepatic outcomes, as well as metabolic disorders like insulin resistance and type 2 diabetes. Aim: The study's purpose is to know if improved diabetic status was correlated with a reduction in systemic oxidative stress following viral eradication in diabetic HCV patients. It also aims to examine the role of systemic IFN-γ production frequency in diabetes managements, as well as its influence on insulin resistance. Patients and methods: The following groups were formed from a total of 115 people: Group 1 consisted of 40 healthy volunteers who served as controls, and Group 2 consisted of 75 diabetic HCV-patients who received direct-acting antiviral regimen (DAA) therapy. Patients were diagnosed at baseline (before) and after therapy with sustained virologic response using laboratory testing. Results: Generally, this study found that HCV clearance significantly ameliorates fasting blood glucose, HbA1c %, and HOMA-IR, as well as MDA, GPX activity, and GSH content, while NF-κB and Nrf2 mRNA expression levels are downregulated and upregulated, respectively. Moreover, the plasma level of IFN-γ was significantly decreased following treatment. Conclusion: The correlation between oxidative stress and viral load, as well as the reduction in MDA and improvement in antioxidant biomarkers, may have a role in diabetes and liver function improvement after HCV eradication. | ||||
| Keywords | ||||
| Hepatitis C virus; Type 2 diabetes mellitus; Lipid peroxidation; Anti-oxidative capability; IFN-&gamma | ||||
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