Metabolite Profiling of Date Palm Fruit (Phoenix dactylifera L.) And Its Cytoprotective Effects Versus Vitamin C Against Mobile Phone Radiation-Induced Adrenal Gland Damage In Rats | ||||
| Zagazig University Medical Journal | ||||
| Article 981, Volume 30, Issue 1.1, January and February 2024, Page 328-341 PDF (1.77 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2022.139449.2569 | ||||
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| Authors | ||||
Rasha Mohamed   1; Maha Abdul Rahman2; may Ahmed El-Sayed3; Mahitab Mostafa Elsayed4; Heba Sabry Ahmed5; Sahar Ali6
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| 1Clinical Pharmacology- Faculty of Medicine- Zagazig University -Zagazig -Egypt | ||||
| 2Department of Human Anatomy and Embryology, Faculty of Medicine, Zagazig University, Egypt | ||||
| 3Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt | ||||
| 4Clinical Pharmacy Department, Faculty of Pharmacy, Modern University for Technology & Information, Cairo, Egypt. | ||||
| 5Department of Clinical Pharmacology, Faculty of Medicine, Zagazig University, 44519 Egypt. | ||||
| 6Clinical Pharmacology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt | ||||
| Abstract | ||||
| Background: Date palm fruit (Phoenix dactylifera L.) can be used as a pharmaceutical product because of its rich phytochemical composition. Mobile phone radiation is a type of electromagnetic radiation (EMR) that has been confirmed to exert several adverse effects on living tissues. Methods: In this study, we investigated the phytochemicals of the Egyptian date palm fruit using ultra-performance liquid chromatography with electrospray ionization quadrupole- linear ion trap tandem mass spectrometry analysis (UPLC-ESI-MS/MS) in negative and positive ionization modes. Adult male Wister albino rats were exposed to mobile phone induced electromagnetic radiations (EMR) for 1 hour per day for 4 weeks. We evaluated the possible cytoprotective effects of date palm fruits compared with vitamin C on mobile phone induced EMR. Rats were divided into the control, EMR, and two EMR groups treated with either vitamin C or date palm fruit. Results: The analysis of date resulted in the tentative identification of 29 compounds, including 13 free organic acids and their derivatives, 9 flavonoids and their glycosides, 3 fatty acids, and 4 miscellaneous compounds. Both biochemical and histopathological examinations of adrenal tissues confirmed that mobile phone radiation caused significant increases in oxidative stress, DNA damage, inflammatory marker levels, fibrosis, and apoptosis in adrenal tissues compared with the control group. Both vitamin C and date palm fruit significantly reduced these damaging effects with superior cytoprotective effect for date palm fruit over vitamin C. Conclusion: Date palm fruits could protect the adrenal glands due to its antiapoptotic, antioxidant, antifibrotic and anti-inflammatory properties. | ||||
| Keywords | ||||
| Date palm fruit (Phoenix dactylifera L); UPLC-ESI-MS/MS; Adrenal gland; Mobile (cell) phone radiation; Tumor necrosis factor α | ||||
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