SYNTHESIS OF POLYFUNCTIONALLY SUBSTITUTED HETEROCYCLIC COMPOUNDS DERIVED FROM 5-CINNAMOYLAMINO-2-CYANOMETHYL-1,3,4-THIADIAZOLE | ||||
| Al-Azhar Bulletin of Science | ||||
| Article 1, Volume 27, Issue 1-A, June 2016, Page 1-8 PDF (342.71 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/absb.2016.24326 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Mahmoud R. Mahmoud; Manal M. El-Shahawi* ; Fatma S. Abu El-Azm; Mohamed Abdeen | ||||
| Chemistry Department, Faculty of Science, Ain Shams University, 11566 Cairo, Egypt. | ||||
| Abstract | ||||
| Cinnamoyl isothiocyanate 1 was reacted with 2-cyanoethanoic acid hydrazide 2 to afford 1-cyanoacetyl-4-substituted thiosemicarbazide 3 which on treatment with a mixture of glacial acetic acid and acetic anhydride gave the desired 5-cinnamoylamino-2-cyanomethyl-1,3,4-thiadiazole 4. Compound 4 was subjected to react with aromatic aldehydes, phenylisothiocyanate, carbon disulphide and arylidene malononitrile to give coumarin 5, thiazolidines 8,9 and 1,3,4-thiadiazolo[3,2-a]pyridine 13 derivatives. The structures of all synthesized compounds were ascertained by spectral and analytical data. | ||||
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