UTILITY OF ENAMINONITRILE IN THE SYNTHESIS OF NOVEL HETEROCYCLES BEARING PYRAZOLE MOIETY AND THEIR ANTIMICROBIAL AND CYTOTOXIC ACTIVITY ASSESSMENT
Sayed, G., Azab, M., Anwer, K., Negm, N. (2016). UTILITY OF ENAMINONITRILE IN THE SYNTHESIS OF NOVEL HETEROCYCLES BEARING PYRAZOLE MOIETY AND THEIR ANTIMICROBIAL AND CYTOTOXIC ACTIVITY ASSESSMENT. EKB Journal Management System, 27(Issue 1-A), 9-22. doi: 10.21608/absb.2016.24327
Galal H. Sayed; Mohamed E. Azab; Kurls E. Anwer; Nabil A. Negm. "UTILITY OF ENAMINONITRILE IN THE SYNTHESIS OF NOVEL HETEROCYCLES BEARING PYRAZOLE MOIETY AND THEIR ANTIMICROBIAL AND CYTOTOXIC ACTIVITY ASSESSMENT". EKB Journal Management System, 27, Issue 1-A, 2016, 9-22. doi: 10.21608/absb.2016.24327
Sayed, G., Azab, M., Anwer, K., Negm, N. (2016). 'UTILITY OF ENAMINONITRILE IN THE SYNTHESIS OF NOVEL HETEROCYCLES BEARING PYRAZOLE MOIETY AND THEIR ANTIMICROBIAL AND CYTOTOXIC ACTIVITY ASSESSMENT', EKB Journal Management System, 27(Issue 1-A), pp. 9-22. doi: 10.21608/absb.2016.24327
Sayed, G., Azab, M., Anwer, K., Negm, N. UTILITY OF ENAMINONITRILE IN THE SYNTHESIS OF NOVEL HETEROCYCLES BEARING PYRAZOLE MOIETY AND THEIR ANTIMICROBIAL AND CYTOTOXIC ACTIVITY ASSESSMENT. EKB Journal Management System, 2016; 27(Issue 1-A): 9-22. doi: 10.21608/absb.2016.24327

UTILITY OF ENAMINONITRILE IN THE SYNTHESIS OF NOVEL HETEROCYCLES BEARING PYRAZOLE MOIETY AND THEIR ANTIMICROBIAL AND CYTOTOXIC ACTIVITY ASSESSMENT

Al-Azhar Bulletin of Science
Article 2, Volume 27, Issue 1-A, June 2016, Page 9-22  XML PDF (500.38 K)
Document Type: Original Article
DOI: 10.21608/absb.2016.24327
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Authors
Galal H. Sayed* 1; Mohamed E. Azab1; Kurls E. Anwer1; Nabil A. Negm2
1Departments of Organic Chemistry Lab., Chemistry, Faculty of Science, Ain Shams University
2Petrochemical, Egyptian Petroleum Research Institute
Abstract
Enaminonitrile derivatives 1a,b were used as a versatile material for the synthesis of different heterocyclic compounds such as pyrazoloacetamide, pyrazolopyrimidinone, pyrazolobenzamide, pyrazolopyrimidines, pyrazolothiazinethiones, pyrazolopyrimidinedithiones, pyrazolocyanoacetamide, pyrazolopyrazoles, tetrazolopyrazoles, pyrazolotetrazolopyrimidines, and pyrazolotetrazolodiazepine derivatives, through the reaction with different electrophiles and nucleophiles. The newly synthesized compound were tested against gram positive and gram negative bacteria, fungi and two human tumor cell lines.
Keywords
pyrazolopyrimidine; pyrazolothiazinethiones; pyrazolotetrazolopyrimidines; pyrazolotetrazolodiazepine; Antimicrobial; Cytotoxic activity
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