REGIOSPECIFIC SYNTHESIS AND RATIONALIZATION OF THE REGIODIVERGENCE SOME SPIROOXINDOLES AS EXPECTED ANTIOXIDANT AGENTS
Rizk, S., Mahmoud, N., Abdelsattar, N., Ali, M. (2016). REGIOSPECIFIC SYNTHESIS AND RATIONALIZATION OF THE REGIODIVERGENCE SOME SPIROOXINDOLES AS EXPECTED ANTIOXIDANT AGENTS. EKB Journal Management System, 27(Issue 1-A), 41-46. doi: 10.21608/absb.2016.24329
Sameh A. Rizk; Naglaa F. Mahmoud; Noueldin A. Abdelsattar; Mai S. Ali. "REGIOSPECIFIC SYNTHESIS AND RATIONALIZATION OF THE REGIODIVERGENCE SOME SPIROOXINDOLES AS EXPECTED ANTIOXIDANT AGENTS". EKB Journal Management System, 27, Issue 1-A, 2016, 41-46. doi: 10.21608/absb.2016.24329
Rizk, S., Mahmoud, N., Abdelsattar, N., Ali, M. (2016). 'REGIOSPECIFIC SYNTHESIS AND RATIONALIZATION OF THE REGIODIVERGENCE SOME SPIROOXINDOLES AS EXPECTED ANTIOXIDANT AGENTS', EKB Journal Management System, 27(Issue 1-A), pp. 41-46. doi: 10.21608/absb.2016.24329
Rizk, S., Mahmoud, N., Abdelsattar, N., Ali, M. REGIOSPECIFIC SYNTHESIS AND RATIONALIZATION OF THE REGIODIVERGENCE SOME SPIROOXINDOLES AS EXPECTED ANTIOXIDANT AGENTS. EKB Journal Management System, 2016; 27(Issue 1-A): 41-46. doi: 10.21608/absb.2016.24329

REGIOSPECIFIC SYNTHESIS AND RATIONALIZATION OF THE REGIODIVERGENCE SOME SPIROOXINDOLES AS EXPECTED ANTIOXIDANT AGENTS

Al-Azhar Bulletin of Science
Article 4, Volume 27, Issue 1-A, June 2016, Page 41-46  XML PDF (395.23 K)
Document Type: Original Article
DOI: 10.21608/absb.2016.24329
View on SCiNiTO View on SCiNiTO
Authors
Sameh A. Rizk1; Naglaa F. Mahmoud2; Noueldin A. Abdelsattar1; Mai S. Ali* 1
1Chemistry Department, Science Faculty, Ain Shams University, Cairo, Egypt 11566
2Chemistry Department, Science Faculty, Ain Shams University, Cairo, Egypt 11566.
Abstract
The spirooxindolo pyrrolidine frameworks form core units of many naturally occurring molecules possess significant pharmacological activities. The [3+2] cycloaddition reactions of azomethine ylides has been realized through multi-component reaction (MCR) affording regiospecific spiroindoline-3, 2’-pyrrolidine derivatives. The reactivity of the spiroindoline (increase EHOMO value) has been depended upon electron repelling and attracting groups. The behavior of spiroindoline towards carbon electrophile and nitrogen nucleophile can be investigated. All compound structures are fully supported by spectroscopic data and elemental analysis.The antioxidant activity for these synthesized compounds could be expected that highly antioxidant activity was with compounds which proved to possess high HOMO values
Keywords
α- amino acids; isatins; azomethine ylides; 4-aryl-4-oxo-2-butenoic acids; indoline; pyrrolidine; spirocyclic; antioxidant agent; HOMO; LUMO
Statistics
Article View: 167
PDF Download: 262