Protective Effects of Rigla, Metformin, or their Combination on STZ-diabetic Hepatotoxicity and Nephrotoxicity in Male Rats
Bahr, N., Abdelkader, A., El Demellawy, M., salah Eldin, A., Ghareeb, D. (2022). Protective Effects of Rigla, Metformin, or their Combination on STZ-diabetic Hepatotoxicity and Nephrotoxicity in Male Rats. EKB Journal Management System, 3(2), 220-234. doi: 10.21608/aujes.2022.128494.1061
Naglaa Bahr; Abdelkader Mohamed Abdelkader; Maha A El Demellawy; Alaa Eldin salah Eldin; Doaa Ghareeb. "Protective Effects of Rigla, Metformin, or their Combination on STZ-diabetic Hepatotoxicity and Nephrotoxicity in Male Rats". EKB Journal Management System, 3, 2, 2022, 220-234. doi: 10.21608/aujes.2022.128494.1061
Bahr, N., Abdelkader, A., El Demellawy, M., salah Eldin, A., Ghareeb, D. (2022). 'Protective Effects of Rigla, Metformin, or their Combination on STZ-diabetic Hepatotoxicity and Nephrotoxicity in Male Rats', EKB Journal Management System, 3(2), pp. 220-234. doi: 10.21608/aujes.2022.128494.1061
Bahr, N., Abdelkader, A., El Demellawy, M., salah Eldin, A., Ghareeb, D. Protective Effects of Rigla, Metformin, or their Combination on STZ-diabetic Hepatotoxicity and Nephrotoxicity in Male Rats. EKB Journal Management System, 2022; 3(2): 220-234. doi: 10.21608/aujes.2022.128494.1061

Protective Effects of Rigla, Metformin, or their Combination on STZ-diabetic Hepatotoxicity and Nephrotoxicity in Male Rats

Aswan University Journal of Environmental Studies
Article 14, Volume 3, Issue 2, June 2022, Page 220-234  XML PDF (491.93 K)
Document Type: Original Research
DOI: 10.21608/aujes.2022.128494.1061
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Authors
Naglaa Bahr email 1; Abdelkader Mohamed Abdelkader2; Maha A El Demellawy3; Alaa Eldin salah Eldin4; Doaa Ghareeb5
1Zoology Department -Faculty of Science -Aswan University
2Professor of Neurophysiology, zoology department, faculty of science, Aswan university
3Medical Biotechnology Department Genetic Engineering & Biotechnology Research Institute (GEBRI). City of Scientific Research & Technological Applications
4Professor of molecular biology, zoology department, faculty of science, Aswan university.
53Biological Screening and Preclinical Trial Lab, Biochemistry Department, Faculty of Science, Alexandria University, Alexandria, Egypt
Abstract
Abstract
The rigla (Portulaca oleracea)is a cosmopolitan species with a diverse variety of biological functions including antioxidant, anti-inflammatory, analgesic and neuroprotective actions. In this research, the aerial parts of Portulaca oleracea were harvested, air dried and powdered. Chemical tests were carried out on the ethanolic extract and the powdered specimen to determine the phytoconstituents using standard procedures. Also, the present study was undertaken to investigate the protective and therapeutic effects of ethanolic extract of Portulaca oleracea on a model of diabetic rats were fed a high-fat diet and injected with a single dose of streptozotocin (STZ) (35mg/kg i.p). Liver enzymes activity, kidney function, lipid profile and glucose level were determined. Diabetic rats were fed a high-fat diet (HFD) exhibited a significant increase in enzymes liver activity (p < 0.05), also, the parameters of kidney function recorded a significant increase (p < 0.05).  In additional, total triglycerides, total cholesterol and glucose level revealed a significant increase (p < 0.05). The diabetic rats treated with ethanolic extract of Portulaca oleracea, metformin (antidiabetic drug) or their combination exhibited a significant decrease (p < 0.05) in liver enzymes activity, kidney function, total triglycerides, total cholesterol and glucose level. The present results confirmed that Portulaca oleracea exhibited a protective effect against oxidative stress.
Keywords
Rigla; HFD; STZ; Liver; Kidney
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