Effect of Prebiotic Inulin Supplementation on Glucose Metabolism and Lipid Profile in Type 2 Diabetic Women
Egila, A., Eltamany, E., Habib, D., Mohamed, N., Youssef, M. (2022). Effect of Prebiotic Inulin Supplementation on Glucose Metabolism and Lipid Profile in Type 2 Diabetic Women. EKB Journal Management System, 65(131), 1521-1526. doi: 10.21608/ejchem.2022.138545.6111
Amr Gamaleldin Egila; Elsayed H Eltamany; Dawoud Fakhry Habib; Nadia Mohamed; Mohamed Fathy Youssef. "Effect of Prebiotic Inulin Supplementation on Glucose Metabolism and Lipid Profile in Type 2 Diabetic Women". EKB Journal Management System, 65, 131, 2022, 1521-1526. doi: 10.21608/ejchem.2022.138545.6111
Egila, A., Eltamany, E., Habib, D., Mohamed, N., Youssef, M. (2022). 'Effect of Prebiotic Inulin Supplementation on Glucose Metabolism and Lipid Profile in Type 2 Diabetic Women', EKB Journal Management System, 65(131), pp. 1521-1526. doi: 10.21608/ejchem.2022.138545.6111
Egila, A., Eltamany, E., Habib, D., Mohamed, N., Youssef, M. Effect of Prebiotic Inulin Supplementation on Glucose Metabolism and Lipid Profile in Type 2 Diabetic Women. EKB Journal Management System, 2022; 65(131): 1521-1526. doi: 10.21608/ejchem.2022.138545.6111

Effect of Prebiotic Inulin Supplementation on Glucose Metabolism and Lipid Profile in Type 2 Diabetic Women

Egyptian Journal of Chemistry
Volume 65, Issue 131, December 2022, Page 1521-1526  XML PDF (348.94 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2022.138545.6111
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Authors
Amr Gamaleldin Egila email 1; Elsayed H Eltamanyorcid 2; Dawoud Fakhry Habib3; Nadia Mohamed4; Mohamed Fathy Yousseforcid 5
1Chemistry Department, Faculty of Science, Suez Canal University, Ismailia, Egypt.
2Professor of Organic chemistry, Chemistry Department, Faculty of Science, Suez Canal University, Ismailia, Egypt.
3Biochemistry-Medical Biochemistry Department, National Research Centre, Cairo, Egypt
4Department of Medical Biochemistry, National Research Centre, Cairo, Egypt.
5Chemistry Department, Faculty of Science, Suez Canal University, Ismailia, Egypt
Abstract
This study determines the effect of insulin administration on fasting blood glucose (FBG), lipid profile "serum triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL) cholesterol, and low-density lipoprotein (LDL) cholesterol), insulin and insulin resistance in women with Type 2 Diabetes (T2DM). T2DM is a multifactorial disease promoted by genetic and environmental factors, and there is a tight association between T2DM and dyslipidemia. Inulin is prebiotic that has been shown to improve insulin concentrations and ameliorate the lipid profile in people with diabetes. 100 T2DM females with predetermined criteria took four grams of inulin-type prebiotic daily for three weeks, with their FBG, Insulin, Insulin resistance (IR), and lipid profile measured before and after. This clinical study demonstrated that the inulin supplementation significantly decreased FBG, serum TG, TC, LDL, insulin, and IR levels and significantly increased HDL compared to the measurements before supplementation. This means that inulin may play a role in correcting the metabolic disorders caused by high fructose diets by improving carbohydrate and lipid metabolism.
Keywords
T2DM; Lipid profile; Inulin; Insulin Resistance; Blood Glucose
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