The Role of early Use of Corticosteroids (Pulse Steroid Versus Regular dose of Steroid) In Patients of Severe Illness of Covid 19
El Gazzar, A., Essawy, T., Abd el Rahman, A., Ahmed, R. (2022). The Role of early Use of Corticosteroids (Pulse Steroid Versus Regular dose of Steroid) In Patients of Severe Illness of Covid 19. EKB Journal Management System, 7(5), 27-35. doi: 10.21608/bjas.2022.244583
A.G. El Gazzar; T.S. Essawy; A.H. Abd el Rahman; R.R. Ahmed. "The Role of early Use of Corticosteroids (Pulse Steroid Versus Regular dose of Steroid) In Patients of Severe Illness of Covid 19". EKB Journal Management System, 7, 5, 2022, 27-35. doi: 10.21608/bjas.2022.244583
El Gazzar, A., Essawy, T., Abd el Rahman, A., Ahmed, R. (2022). 'The Role of early Use of Corticosteroids (Pulse Steroid Versus Regular dose of Steroid) In Patients of Severe Illness of Covid 19', EKB Journal Management System, 7(5), pp. 27-35. doi: 10.21608/bjas.2022.244583
El Gazzar, A., Essawy, T., Abd el Rahman, A., Ahmed, R. The Role of early Use of Corticosteroids (Pulse Steroid Versus Regular dose of Steroid) In Patients of Severe Illness of Covid 19. EKB Journal Management System, 2022; 7(5): 27-35. doi: 10.21608/bjas.2022.244583

The Role of early Use of Corticosteroids (Pulse Steroid Versus Regular dose of Steroid) In Patients of Severe Illness of Covid 19

Benha Journal of Applied Sciences
Article 5, Volume 7, Issue 5, May 2022, Page 27-35  XML PDF (397.07 K)
Document Type: Original Research Papers
DOI: 10.21608/bjas.2022.244583
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Authors
A.G. El Gazzar1; T.S. Essawy1; A.H. Abd el Rahman2; R.R. Ahmed3
1Chest Diseases, Dept., Faculty of Medicine, Benha Univ., Benha, Egypt
2Anesthesia and intensive care , Dept., Faculty of Medicine, Benha Univ., Benha, Egypt
3Critical care medicine Dept., Faculty of Medicine, Benha Univ., Benha, Egypt
Abstract
Background: Coronaviruses are ribonucleic acid viruses, in humans the viruses may infect the respiratory, gastrointestinal, hepatic, and central nervous systems. Infection with four of the most common coronaviruses strains. usually lead to mild, self-limiting upper respiratory tract infections However, other corona viruses, are associated with severe acute respiratory syndrome (SARS-CoV) and the Middle East respiratory syndrome (MERS-CoV). Aim: to assess the use of systemic steroid either pulse steroid or regular dose of steroid in patient with severe form of covid 19 as regard hospital stay, need for mechanical ventilation. Methods: a cross sectional study, carried out on 50 patients who were suspected with covid 19 by history, laboratory investigation, chest imaging and confirmed with PCR selected from the critical care unit and isolation critical care unit at Benha university Hospital. And were classified into two groups, Group1: 25 patients were received dexamethasone (8 mg per day) and Group 2:  25 patients were received solumedrol (2mg per Kg). All data will be tabulated and statistically analyzed. Results: the mean ICU length of stay in critically ill patients who received Dexamethasone was 12.5±4.286 versus 14.68±7.851 in critically ill patients who received Methylprednisolone (p-value=0.08).  Patients in Dexamethasone group, by the 10th day, had a significantly better D dimer (1153.04±725.34 vs 1633.12±1244.8, p=0.020), ferritin, (899.14±344.22 vs 1523.8±994.44, p < 0.001), NLR (3.108±0.430 vs 3.506±0.536, p < 0.001), however, Methyl prednisolone group had lower mortality rate (p0.001). Conclusion Covid 19 is global pandemic with worldwide mortality rate that need urgent interventions from all world to face this catastrophe. However, ICU stay, d dimer, ferritin, NLR among patients who treated with Dexamethasone lower than among patients who treated with Methylprednisolone, those treated with Methylprednisolone had better mortality rates.
Keywords
Covid 19; pandemics; SARS viruses; ARDS; Corticosteroids
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