Diacerein protects against renal ischemia/reperfusion-induced kidney and lung injuries: involvement of osteopontin and Nrf-2/HO-1 pathway. | ||||
| Zagazig University Medical Journal | ||||
| Article 2, Volume 30, Issue 1, January and February 2024, Page 14-23 PDF (2 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2022.126747.2499 | ||||
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| Authors | ||||
Nisreen Elnagy Elwany   1; Heba sabry Ahmed2; Nevertyty Mohamed Mahmoud3
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| 1Clinical Pharmacology department, faculty of medicine, zagazig University, Egypt | ||||
| 2Clinical Pharmacology Department, Faculty of Medicine, Zagazig, University, Egypt | ||||
| 3Clinical pharmacology department, Faculty of Medicine, Zagazig University, Egypt | ||||
| Abstract | ||||
| Background: Renal ischemia/reperfusion is an imperative cause of acute kidney damage which in turn releases detrimental mediators into the circulation leading to subsequent remote organ injury. The current study attempted to assess the possible protective effects of diacerein (DIA), an interleukin-1 receptor antagonist, against renal ischemia/reperfusion (I/R) induced kidney and lung injuries in male albino rats. Methods: Rats were randomly assigned into: sham, I/R, and DIA-pretreated I/R groups. DIA was orally administered in doses of 25, 50 and 100 mg/kg/day for 20 days, then, both right and left renal pedicles were clamped for 45 min followed by reperfusion for 24 h. One-way ANOVA followed by Post-Hoc test were used to compare the results. P-Value of | ||||
| Keywords | ||||
| diacerein; osteopontin; renal injury; lung injury | ||||
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