Pharmacodynamics evaluation of Eggplant wastes formulated as lyophilized tablets in an attempt for preparation of a bioactive natural antidiabetic dosage form
EL Bazzar, H., Mohamed, S., Mahmoud, Y., Bazan, L., Ibrahim, N., Mahmoud, R., Abou El Ezz, R., Ibrahim, H., Afifi, M. (2022). Pharmacodynamics evaluation of Eggplant wastes formulated as lyophilized tablets in an attempt for preparation of a bioactive natural antidiabetic dosage form. EKB Journal Management System, 2(1), 74-83. doi: 10.21608/jfcr.2022.245600
Hana EL Bazzar; Sohayla Mohamed; Yomna Mahmoud; Lamia Bazan; Noha Ibrahim; Rasha Mahmoud; Rania Abou El Ezz; Hany Mahmoud Ibrahim; Manal Afifi. "Pharmacodynamics evaluation of Eggplant wastes formulated as lyophilized tablets in an attempt for preparation of a bioactive natural antidiabetic dosage form". EKB Journal Management System, 2, 1, 2022, 74-83. doi: 10.21608/jfcr.2022.245600
EL Bazzar, H., Mohamed, S., Mahmoud, Y., Bazan, L., Ibrahim, N., Mahmoud, R., Abou El Ezz, R., Ibrahim, H., Afifi, M. (2022). 'Pharmacodynamics evaluation of Eggplant wastes formulated as lyophilized tablets in an attempt for preparation of a bioactive natural antidiabetic dosage form', EKB Journal Management System, 2(1), pp. 74-83. doi: 10.21608/jfcr.2022.245600
EL Bazzar, H., Mohamed, S., Mahmoud, Y., Bazan, L., Ibrahim, N., Mahmoud, R., Abou El Ezz, R., Ibrahim, H., Afifi, M. Pharmacodynamics evaluation of Eggplant wastes formulated as lyophilized tablets in an attempt for preparation of a bioactive natural antidiabetic dosage form. EKB Journal Management System, 2022; 2(1): 74-83. doi: 10.21608/jfcr.2022.245600

Pharmacodynamics evaluation of Eggplant wastes formulated as lyophilized tablets in an attempt for preparation of a bioactive natural antidiabetic dosage form

Journal of Fundamental and Clinical Research
Article 6, Volume 2, Issue 1, June 2022, Page 74-83  XML PDF (391.98 K)
Document Type: Original research articles
DOI: 10.21608/jfcr.2022.245600
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Authors
Hana EL Bazzar1; Sohayla Mohamed2; Yomna Mahmoud2; Lamia Bazan3; Noha Ibrahim4; Rasha Mahmoud4; Rania Abou El Ezz5; Hany Mahmoud Ibrahim email orcid 6; Manal Afifi5
1Senior Students, Faculty of Pharmacy, Misr International University (MIU), Cairo, Egypt.
2Senior Student, Faculty of Pharmacy, Misr International University, Cairo, Egypt.
3Pharmaceutical Technology Department, Faculty of Pharmacy, Misr International University, Cairo, Egypt. Misr International University, Cairo, Egypt.
4Pharmaceutical Chemistry Department, Faculty of Pharmacy, Misr International University, Cairo, Egypt.
5Pharmacognosy Department, Faculty of Pharmacy, Misr International University, (MIU), Cairo Egypt.
6Pharmaceutical Technology Department, Faculty of Pharmacy, Misr International University (MIU),Cairo, Egypt
Abstract
Introduction: Eggplant fruits (Solanum melongena L.) are widely consumed worldwide due to their generous composition of nutraceuticals. They are enriched with different classes of phenolic phytochemicals. Among the polyphenolic constituents, the fruit peels show high content of quercetin-3-rutinoside, chlorogenic acid and delphinidine-3-rutinoside. The plant possesses various biological activities such as antioxidant and antidiabetic activities. It can manage type 2 diabetes by controlling glucose absorption. Aim of study: The objective of the present study was to standardize delphinidine-3-rutinoside, chlorogenic acid, and quercetin-3-rutinoside, present in the eggplant peels extract, then formulate the extract as a lyophilized tablet, in order to evaluate its effect on glucose levels in an attempt for preparation of a bioactive natural antidiabetic dosage form. Materials and Methods: Various extracts of Eggplant peels were prepared using different extraction solvents. Pharmacodynamics studies were carried out on formulated lyophilized tablets containing the most promising extract.  Pharmacodynamics study was conducted to assess the effect of the fruit peels extract on the management of blood glucose level in diabetic rats. Results: The results revealed that the Eggplant fruit peels extract in the form of lyophilized tablets could be promising in controlling the high blood glucose level in type 2 diabetic patients, as the freeze-dried tablets of the Eggplant peels extract resulted in lowering the blood glucose level to ~148 mg/dl after 10 days of twice daily administrations to diabetic rats. Conclusion:this report, addresses the important approach of finding and exploiting the significance of using food wastes in drug discovery.
Keywords
Eggplant peels; anthocyanins - pharmacodynamics- antidiabetic
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