Hepatoprotective Effect of Jojoba Oil and Nigella Sativa Seeds in Rats Fed Diet Containing Aflatoxin
Sobhy, H., Abo Elmagd, M., El-kholy, M., Abo Elmagd, E., Laz, E. (2016). Hepatoprotective Effect of Jojoba Oil and Nigella Sativa Seeds in Rats Fed Diet Containing Aflatoxin. EKB Journal Management System, 2(2), 21-37. doi: 10.21608/ejceh.2016.246166
Hanan M Sobhy; Mohammed K Abo Elmagd; Maha M El-kholy; Enas K Abo Elmagd; Eman Sh Laz. "Hepatoprotective Effect of Jojoba Oil and Nigella Sativa Seeds in Rats Fed Diet Containing Aflatoxin". EKB Journal Management System, 2, 2, 2016, 21-37. doi: 10.21608/ejceh.2016.246166
Sobhy, H., Abo Elmagd, M., El-kholy, M., Abo Elmagd, E., Laz, E. (2016). 'Hepatoprotective Effect of Jojoba Oil and Nigella Sativa Seeds in Rats Fed Diet Containing Aflatoxin', EKB Journal Management System, 2(2), pp. 21-37. doi: 10.21608/ejceh.2016.246166
Sobhy, H., Abo Elmagd, M., El-kholy, M., Abo Elmagd, E., Laz, E. Hepatoprotective Effect of Jojoba Oil and Nigella Sativa Seeds in Rats Fed Diet Containing Aflatoxin. EKB Journal Management System, 2016; 2(2): 21-37. doi: 10.21608/ejceh.2016.246166

Hepatoprotective Effect of Jojoba Oil and Nigella Sativa Seeds in Rats Fed Diet Containing Aflatoxin

Egyptian Journal of Chemistry and Environmental Health
Volume 2, Issue 2, November 2016, Page 21-37  XML PDF (365.02 K)
Document Type: Scientific and Research
DOI: 10.21608/ejceh.2016.246166
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Authors
Hanan M Sobhy email 1; Mohammed K Abo Elmagd1; Maha M El-kholy1; Enas K Abo Elmagd2; Eman Sh Laz1
1Biochem.Toxicol &Feed Deff. Dep. AHRI ,Dokki ,Giza
2microbiology Dep.- Faculty of medicine for girls – Al-Azhar university
Abstract
Aim: This study aimed to evaluate the hepatoprotective effect of Jojoba oil(J.O.) and Nigella sativa seeds(N.S.) in rats fed diet contaminated with aflatoxin(AF).
Methods: Forty mature male rats were divided into eight groups and treated for 30 days as follows: (1) Untreated control; (2) Jojoba oil 1.25% (low concentration) ; (3) Jojoba oil 2.5% (high concentration) ; (4) Aflatoxin (AF)-contaminated diet (30ug/kg diet); (5) low dose Jojoba oil plus AF; (6) high dose Jojoba oil plus AF; (7) Nigella sativa seeds at 2.5% and (8) Nigella sativa seeds plus AF. Blood samples were collected for biochemical analyses and livers were taken DNA measurement.
Results: The results indicated that Jojoba oil is rich in protein, phenolic compounds, phytic acid, and considerable amounts of simmondsin. Animals fed AF - contaminated diet showed severe biochemical changes and DNA damage. Feeding on ration mixed with Jojoba oil alone at the two tested concentrations or Nigella sativa seeds did not induce significant alterations in all tested parameters. Treatment with Jojoba oil to rats fed AF containing diet protected against hepatotoxicity and DNA damage induced by AF.
Conclusion: It can be concluded that Jojoba oil and Nigella sativa seeds can be incorporated in AF-contaminated feed to protect against hepatotoxicity and DNA damage induced by AF.
Keywords
Jojoba oil; Nigilla sativa & Aflatoxin
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