Molecular mechanism of Copper Albumin Complex on NDEA induced brain vascular damage via promoting VEGF expression.
taha, L., Maher, Z., Nassar, A., Abdallah, M., embark, H., Youssef, M., Abdeen, A., Moftah, R., Madhyastha, H., Shanab, O. (2022). Molecular mechanism of Copper Albumin Complex on NDEA induced brain vascular damage via promoting VEGF expression.. EKB Journal Management System, 5(2), 68-76. doi: 10.21608/svu.2022.133515.1192
laila taha; Zainab M Maher; Ahmed Y Nassar; Mohamed s Abdallah; hamdy embark; Mohammed Youssef; Ahmed Abdeen; Rofida F. Moftah; Harishkumar Madhyastha; Obeid Shanab. "Molecular mechanism of Copper Albumin Complex on NDEA induced brain vascular damage via promoting VEGF expression.". EKB Journal Management System, 5, 2, 2022, 68-76. doi: 10.21608/svu.2022.133515.1192
taha, L., Maher, Z., Nassar, A., Abdallah, M., embark, H., Youssef, M., Abdeen, A., Moftah, R., Madhyastha, H., Shanab, O. (2022). 'Molecular mechanism of Copper Albumin Complex on NDEA induced brain vascular damage via promoting VEGF expression.', EKB Journal Management System, 5(2), pp. 68-76. doi: 10.21608/svu.2022.133515.1192
taha, L., Maher, Z., Nassar, A., Abdallah, M., embark, H., Youssef, M., Abdeen, A., Moftah, R., Madhyastha, H., Shanab, O. Molecular mechanism of Copper Albumin Complex on NDEA induced brain vascular damage via promoting VEGF expression.. EKB Journal Management System, 2022; 5(2): 68-76. doi: 10.21608/svu.2022.133515.1192

Molecular mechanism of Copper Albumin Complex on NDEA induced brain vascular damage via promoting VEGF expression.

SVU-International Journal of Veterinary Sciences
Article 7, Volume 5, Issue 2 - Serial Number 12, June 2022, Page 68-76  XML PDF (678.74 K)
Document Type: Research article
DOI: 10.21608/svu.2022.133515.1192
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Authors
laila taha email 1; Zainab M Maher2; Ahmed Y Nassar3; Mohamed s Abdallah4; hamdy embark5; Mohammed Youssef5; Ahmed Abdeen6; Rofida F. Moftah7; Harishkumar Madhyastha8; Obeid Shanaborcid 9
1biochemistry,faculty of veterinary medicine,south valley univercity,qena,egypt
2Department of Pathology and clinical pathology, Faculty of veterinary medicine, Qena university
33Department of Medical Biochemistry and Molecular biology, Faculty of Medicine, Assiut University, Assiut, Egypt.
4Department of Biochemistry, Faculty of Veterinary Medicine, South Valley University, Qena 83523, Egypt.
5Department of Animal Physiology, Faculty of Veterinary Medicine, South Valley University, Qena 83523, Egypt
6Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Benha University, Toukh, Egypt.Center of Excellence for Screening of Environmental Contaminants (CESEC), Faculty of Veterinary Medicine, Benha University, Toukh, Egypt.
7Food Science and Technology Department, Faculty of Agriculture, Assiut University, Assiut, Egypt.
8Department of Cardiovascular Physiology, Faculty of medicine, University of Miyazaki, Miyazaki 8891692, Japan.
9Department of Biochemistry, faculty of veterinary medicine, South Valley University, Egypt.
Abstract
Nitrosodiethylamine (NDEA) is a potent oxidant induces neurodegeneration via (reactive oxgen species) ROS. Copper is an important metal essential for scavenging free radicals, development of central nervous system (CNS) and redox angiogenesis signaling. Vascular endothelial growth factor (VEGF) is well known as efficacious and long-term signal that stimulates angiogenesis, where its expression is copper dependent.We examined thecopper protective effect against brain vascular damage initiated by NDEA. NDEA induces brain vascular wall damage, necrosis with interstitial hemorrhage and diminishesVEGF expression. Histopathological examination showing a great improvement of brain tissue in copper treated mice with significant increase in VEGF expression.Higher levels of intracellular copper can stimulate angiogenesis and exhibited a significant protection against NDEA induced brain vascular damage,confirming its ability to enhanceantioxidant activity andangiogenesis initiation.Our report presents first evidence that inducible VEGF expression in brain is sensitive to copper; moreover Copper based therapeutics represents a novel approach to reducebrain vascular damage induced by NDEA generated ROS.
Keywords
Nitrosamines; Copper; VEGF; ROS; NDEA
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