A Review Article on The Investigation of Therapeutic Potential of Sildenafil in Experimentally-Induced Hind Limb Ischemia of Diabetic Model
Tawfik, K., Hazem, R., Hanna, P., El-Azab, M., Moustafa, Y. (2022). A Review Article on The Investigation of Therapeutic Potential of Sildenafil in Experimentally-Induced Hind Limb Ischemia of Diabetic Model. EKB Journal Management System, 6(3), 86-112. doi: 10.21608/rpbs.2022.132107.1134
Karim Tawfik; Reem M. Hazem; Pierre A. Hanna; Mona Farag El-Azab; Yasser Moustafa. "A Review Article on The Investigation of Therapeutic Potential of Sildenafil in Experimentally-Induced Hind Limb Ischemia of Diabetic Model". EKB Journal Management System, 6, 3, 2022, 86-112. doi: 10.21608/rpbs.2022.132107.1134
Tawfik, K., Hazem, R., Hanna, P., El-Azab, M., Moustafa, Y. (2022). 'A Review Article on The Investigation of Therapeutic Potential of Sildenafil in Experimentally-Induced Hind Limb Ischemia of Diabetic Model', EKB Journal Management System, 6(3), pp. 86-112. doi: 10.21608/rpbs.2022.132107.1134
Tawfik, K., Hazem, R., Hanna, P., El-Azab, M., Moustafa, Y. A Review Article on The Investigation of Therapeutic Potential of Sildenafil in Experimentally-Induced Hind Limb Ischemia of Diabetic Model. EKB Journal Management System, 2022; 6(3): 86-112. doi: 10.21608/rpbs.2022.132107.1134

A Review Article on The Investigation of Therapeutic Potential of Sildenafil in Experimentally-Induced Hind Limb Ischemia of Diabetic Model

Records of Pharmaceutical and Biomedical Sciences
Article 7, Volume 6, Issue 3, April 2022, Page 86-112  XML PDF (1.69 MB)
Document Type: Original Article
DOI: 10.21608/rpbs.2022.132107.1134
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Authors
Karim Tawfik email 1; Reem M. Hazemorcid 2; Pierre A. Hanna3; Mona Farag El-Azaborcid 4; Yasser Moustafaorcid 5
1Pharmacology & Toxicology Department, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.
2Pharmacology & Toxicology Department, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.
3Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.
4Department of Pharmacology and Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt
5Pharmacology and Toxicology Department, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.
Abstract
Sildenafil citrate is a highly selective inhibitor of cyclic guanine monophosphate-specific phosphodiesterase type-5 (PDE-5), leads to smooth muscle relaxation, increases vascular perfusion and tissue blood flow. Clinical and experimental studies previously reported a protective effect of sildenafil in ischemic reperfusion settings in various models. Antioxidants have been reported to reduce ischemia reperfusion injury like vitamin E. Selenium (Se) is one of the most important antioxidants. Antioxidant enzymes such as thioredoxin reductase (TrxR) and glutathione peroxidase along with selenoprotein-P, are responsible for the transport and storage of Se. Nano-elemental Se (SeNPs) are more biocompatible with exhibiting a dramatic decrease in toxicity. Sildenafil and Nano selenium mediated therapeutic angiogenesis in diabetic hind limb ischemia. They improve blood supply, antioxidants delivery for cells and decrease necrosis in peripheral arterial disease (PAD). The induction of therapeutic angiogenesis by sildenafil and SeNPs achieved in this study along with resumed antioxidant defense gives hope of an alternative treatment
Keywords
Sildenafil citrate; Nano-selenium; Hind limb ischemia
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