First- and Second-Derivative Spectrophotometry for Simultaneous Determination of lorazepam and clonazepam in pharmaceutical formulations.

Zankanah, Faeza H.; Al Ani, Fatma A. A.; Shaker, Ala’a R.; Taha, Ahmed b.; Abdulraheem, Mohammed S.

doi:10.21608/ejchem.2022.130646.5753

	First- and Second-Derivative Spectrophotometry for Simultaneous Determination of lorazepam and clonazepam in pharmaceutical formulations.
Egyptian Journal of Chemistry
Volume 66, Issue 3, March 2023, Page 271-280 PDF (1.33 MB)
Document Type: Original Article
DOI: 10.21608/ejchem.2022.130646.5753
View on SCiNiTO
Authors
Faeza H. Zankanah ¹; Fatma A. A. Al Ani²; Ala’a R. Shaker¹; Ahmed b. Taha¹; Mohammed S. Abdulraheem³
¹College of Health & Medical Technology, Uruk University, Baghdad-Iraq.
²Department of Chemistry, College of Education for Pure Science/ Ibn Al-Haitham, Adhamiya, University of Baghdad, Baghdad-Iraq.
³Ministry of Education, Baghdad College, Baghdad-Iraq.
Abstract
The present study describes employing zero-, 1st - and 2nd -order derivative spectrophotometric methods have been developed for determination of lorazepam (LORA) and clonazepam (CLON) in commercially available tablets. LORA was determined by means of 1st (D1), 2nd (D2) derivative spectrophotometric techniques using zero cross, peak height, and Peak area. D1 used for the determination of CLON by using zero cross and peak height while D2 (zero cross) was used for the determination of CLON. The method was established to be linear in concentration containing different ratios of LORA and CLON range of (20-200 mg/L) and (5-35 mg/L) at wavelength range (250 -370 nm), (210-370nm) respectively. The proposed techniques are highly sensitive, precise and accurate and can be used for the reliable quantitation of lorazepam and clonazepam in tablet formulation
Keywords
first- and second derivative spectroscopy; lorazepam; clonazepam


Statistics Article View: 504 PDF Download: 219