Effect of exposure to formalin on the histochemical structure of respiratory organs in Mice
Alaa-Eldein, S., Hafez, E., soliman, S., Abdelsabour-Khalaf, M. (2022). Effect of exposure to formalin on the histochemical structure of respiratory organs in Mice. EKB Journal Management System, 5(2), 91-105. doi: 10.21608/svu.2022.131346.1187
Samah M. Alaa-Eldein; Enas A. Hafez; Soha soliman; Mohammed Abdelsabour-Khalaf. "Effect of exposure to formalin on the histochemical structure of respiratory organs in Mice". EKB Journal Management System, 5, 2, 2022, 91-105. doi: 10.21608/svu.2022.131346.1187
Alaa-Eldein, S., Hafez, E., soliman, S., Abdelsabour-Khalaf, M. (2022). 'Effect of exposure to formalin on the histochemical structure of respiratory organs in Mice', EKB Journal Management System, 5(2), pp. 91-105. doi: 10.21608/svu.2022.131346.1187
Alaa-Eldein, S., Hafez, E., soliman, S., Abdelsabour-Khalaf, M. Effect of exposure to formalin on the histochemical structure of respiratory organs in Mice. EKB Journal Management System, 2022; 5(2): 91-105. doi: 10.21608/svu.2022.131346.1187

Effect of exposure to formalin on the histochemical structure of respiratory organs in Mice

SVU-International Journal of Veterinary Sciences
Article 9, Volume 5, Issue 2 - Serial Number 12, June 2022, Page 91-105  XML PDF (2.14 MB)
Document Type: Research article
DOI: 10.21608/svu.2022.131346.1187
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Authors
Samah M. Alaa-Eldein email 1; Enas A. Hafez2; Soha soliman1; Mohammed Abdelsabour-Khalaforcid 3
1Department of Histology, Faculty of Veterinary Medicine, South Valley University, Qena 83523, Egypt
2Department of Histology, Faculty of Veterinary Medicine, Assuit University, Assuit, Egypt
3Department of Anatomy and Embryology, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt
Abstract
This study evaluated the histopathological changes in lung tissue induced by formaldehyde vapors in mice. A group of 20 adult male mice was divided into two groups for this purpose. The mice in group (I) are the controls, whereas the mice in groups (II) were exposed to formaldehyde vapors inhalation in a toxic dose (0.5 part per thousand) everyday for two months in the students dissecting room of South Valley University's Faculty of Veterinary Medicine. Lung samples were prepared for light microscopic examination after exposure. Gross structural abnormalities in the lungs were identified, including congestion in most lobes and localized pneumonic organization. Thickening of the alveolar septum, epithelial hyperplasia in the bronchioles, proliferative capillaries, pulmonary vasculitis, hyperplastic lymphocytic aggregations in the parabronchiolar area, pulmonary fibrosis, and precancerous modifications were detected under light microscopy (metaplasia of goblet cells and dysplasia of the bronchiolar epithelium). It was found that inhaling formaldehyde has an irritating toxic effect in addition to its harmful carcinogenic effect on the lungs of mice, which is related to exposure durations.
Keywords
Formaldehyde; mice lung, Fibrosis, lymphoid hyperplasia
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