Comparative study of cytotoxic properties of nanoliposomal form of Curcumin or vitamin E towards laryngeal carcinoma | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 66, Issue 3, March 2023, Page 359-370 PDF (1.34 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2022.137980.6076 | ||||
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| Authors | ||||
Naglaa M. Ismail  1; Medhat W. Shafaa2; Maha R. Elsyed1
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| 1Physics Department, Biophysics Division, Faculty of Women for Arts, Science and Education. Ain Shams University. Cairo. Egypt. | ||||
| 2Physics Department, Medical Biophysics Division, Faculty of Sciences, Helwan University, Cairo, Egypt. | ||||
| Abstract | ||||
| This study aimed to investigate in vitro the effect of Curcumin and Vitamin E by using liposome as a drug-delivery system and evaluate the cytotoxic potential of these liposome using laryngeal carcinoma Hep-2 cell line. Curcumin and Vitamin E liposomes were characterized in terms of size distribution, ζ-potential, Fourier transform infrared (FT-IR) spectroscopy and Differential scanning calorimetry (DSC). In the cell count assay, the viability of cells decreased as the concentration of the compounds increased. The cell viability declined to about 4.5% at a concentration of 400 µM for Curcumin and Curcumin-loaded liposomes, while declined to about 52.1% and 53.6 % at a concentration of 400 µM for Vitamin E and Vitamin E loaded liposomes respectively. Finally, this result indicates that Curcumin and its liposomal form have strong inhibition of cell growth and continually increasing inhibition with increased concentrations against Hep-2 cell line. vitamin E showed limited effect on Hep-2 cancer cells, while Curcumin combined with Vitamin E or its liposomal forms indicated a significant reduction in the cell viability when tested at the same concentration (400 µg/ml). | ||||
| Keywords | ||||
| Curcumin; vitamin E; hep-2; liposomes; ft-ir; cytotoxicity | ||||
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