SERODIAGNOSIS OF EARLY NEONATAL SEPSIS IN EGYPTIAN NEONATES | ||||
| Al-Azhar Journal of Pediatrics | ||||
| Article 6, Volume 25, Issue 1, January 2022, Page 2463-2482 PDF (194.62 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/azjp.2022.247418 | ||||
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| Abstract | ||||
| Background: Neonatal sepsis is a life-threatening disease. Early diagnosis is essential, but no single marker of infection has been identified. Sepsis activates a coagulation cascade with simultaneous production of the D-dimers due to lysis of fibrin. D-dimer test reflects the activation of the coagulation system. Aim and objectives: the main aim of this study was to evaluate the level of D-dimer in neonatal sepsis as a diagnostic test and if has a role in the severity or complications of neonatal sepsis. Subjects and methods: This was cross-sectional study that conducted in the tertiary care NICU of Bab El-sheria and Al- Hussein University Hospitals, Al-Azhar University. This study was conducted on 40 septic newborns (Patients group), and 40 non-septic newborns served as Control group. Results: There was high positive significant correlation between D-dimer and mortality (r=0.858, P<0.001), and there was high positive significant correlation between D-dimer and I/T ratio and high negative significant correlation with PLT. Conclusion: D-dimer is a sensitive predictor of sepsis in neonates with sensitivity 80%, specificity 96%, negative predictive value 88.9% and positive predictive value 92.3%. Hence, it should be included in the septic screening of newborns. | ||||
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