Profiling of nosocomial infection in hepatic patients
khalil, F., Abed El motaleb, T., Abed El-kareem, M., Elsheikh, I., Ghoneim, E. (2022). Profiling of nosocomial infection in hepatic patients. EKB Journal Management System, 3(3), 657-667. doi: 10.21608/mid.2022.144976.1325
fatma khalil; Tawfik Abed El motaleb; Mervat Abed El-kareem; Islam Elsheikh; Enas M Ghoneim. "Profiling of nosocomial infection in hepatic patients". EKB Journal Management System, 3, 3, 2022, 657-667. doi: 10.21608/mid.2022.144976.1325
khalil, F., Abed El motaleb, T., Abed El-kareem, M., Elsheikh, I., Ghoneim, E. (2022). 'Profiling of nosocomial infection in hepatic patients', EKB Journal Management System, 3(3), pp. 657-667. doi: 10.21608/mid.2022.144976.1325
khalil, F., Abed El motaleb, T., Abed El-kareem, M., Elsheikh, I., Ghoneim, E. Profiling of nosocomial infection in hepatic patients. EKB Journal Management System, 2022; 3(3): 657-667. doi: 10.21608/mid.2022.144976.1325

Profiling of nosocomial infection in hepatic patients

Microbes and Infectious Diseases
Article 17, Volume 3, Issue 3, August 2022, Page 657-667  XML PDF (412.94 K)
Document Type: Original Article
DOI: 10.21608/mid.2022.144976.1325
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Authors
fatma khalil email orcid 1; Tawfik Abed El motaleb1; Mervat Abed El-kareem2; Islam Elsheikh3; Enas M Ghoneim4
1Clinical and Molecular Microbiology and Immunology Department, National Liver Institute, Menoufia University, Shebin El-kom, Egypt
2Hepatology and Gastrology Department, National Liver Institute, Menoufia University, Shebin El-kom, Egypt
3Infection Control Department, Directorate of Health Affairs, Ministry of Health Shebin El-kom , Egypt
4Professor of Medical Microbiology and Immunology and head of Clinical Microbiology and Immunology department, National Liver Institute, Menoufia University, Shebin El-kom 32511, Egypt
Abstract
Background: Nosocomial infection (NCI) is a problem with global concern due to increasing morbidity and mortality in hospitalized patients. Chronic liver disease increases the chance of NCI by suppressing cell and antibody mediated immunity. Aim: We aimed in this study to visualize the problem of NCI in hepatic patients regarding organisms causing it, pattern of resistance and possible device associated with its existence. Methods: End stage chronic hepatitis C patients who admitted to the National Liver Institute Hospital, Menoufia University, were enrolled in this observational study. Different samples from alleged sites further processed by conventional culture and sensitivity techniques and confirmed by VITEK2C2 system. Antibiotic resistance pattern of isolates was assessed.  Pan drug resistance  (PDR) Acinetobacter baumannii to Omp A, bap, and Csu E virulence genes was further processed by Multiplex PCR.  Results: Gram- negative pathogens were significantly higher in CAUTI. The most predominant nosocomial organism was Pseudomonas aeruginosa which represent 19% (32 from 168), followed by Staph aureus that account for 17.86% (30 from 168), Acinetobacter baumannii signify 14.2%, Klebsiella pneumonia form 11.9%. MDR represents 123 isolates from 168 with 73.2% percentage, while XDR represents 23.8% of total isolates.  Pan drug resistance Acinetobacter baumannii represents 5 from 24 isolates. It was associated with CAUTI and CLBSI but non-significant. 4 PDR isolates show Prescence of Omp A, Csu E, and bap biofilm forming genes. Conclusions: MDR NCI in hepatic patients need more attention regarding rational use of antibiotics especially with appearance of PDR Acinetobacter baumannii carrying Omp A, Csu E, and bap biofilm forming genes.
Keywords
Nosocomial infection; Hepatic patients; PDR; Acinetobacter baumannii
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