COMPARATIVE STUDY BETWEEN METFORMIN AND INSULIN USE ON COGNITIVE STATUS IN TYPE 2 DIABETIC EGYPTIAN PATIENTS
Abd elaaty, T., Elnily, D., Badrah, M., Khalil Nawar, A. (2022). COMPARATIVE STUDY BETWEEN METFORMIN AND INSULIN USE ON COGNITIVE STATUS IN TYPE 2 DIABETIC EGYPTIAN PATIENTS. EKB Journal Management System, 4(3), 1-2. doi: 10.21608/alexpo.2022.148762.1428
Talaat Abd elaaty; Dalia Abd Elmoate Elnily; Mai Hesham Badrah; Amany Ali Khalil Nawar. "COMPARATIVE STUDY BETWEEN METFORMIN AND INSULIN USE ON COGNITIVE STATUS IN TYPE 2 DIABETIC EGYPTIAN PATIENTS". EKB Journal Management System, 4, 3, 2022, 1-2. doi: 10.21608/alexpo.2022.148762.1428
Abd elaaty, T., Elnily, D., Badrah, M., Khalil Nawar, A. (2022). 'COMPARATIVE STUDY BETWEEN METFORMIN AND INSULIN USE ON COGNITIVE STATUS IN TYPE 2 DIABETIC EGYPTIAN PATIENTS', EKB Journal Management System, 4(3), pp. 1-2. doi: 10.21608/alexpo.2022.148762.1428
Abd elaaty, T., Elnily, D., Badrah, M., Khalil Nawar, A. COMPARATIVE STUDY BETWEEN METFORMIN AND INSULIN USE ON COGNITIVE STATUS IN TYPE 2 DIABETIC EGYPTIAN PATIENTS. EKB Journal Management System, 2022; 4(3): 1-2. doi: 10.21608/alexpo.2022.148762.1428

COMPARATIVE STUDY BETWEEN METFORMIN AND INSULIN USE ON COGNITIVE STATUS IN TYPE 2 DIABETIC EGYPTIAN PATIENTS

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Article 3, Volume 4, Issue 3, September 2022, Page 1-2  XML
Document Type: Preliminary preprint short reports of original research
DOI: 10.21608/alexpo.2022.148762.1428
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Authors
Talaat Abd elaaty1; Dalia Abd Elmoate Elnily2; Mai Hesham Badrah3; Amany Ali Khalil Nawar email 4
1Department of Internal Medicine, Faculty of Medicine, University of Alexandria
2Department of clinical and chemical pathology Faculty of Medicine Alexandria University
3Department of Internal Medicine Faculty of Medicine Alexandria University
4Department of clinical pharmacology, Faculty of Medicine, Alexandria University
Abstract
INTRODUCTION:
Diabetes mellitus is a serious, long-term disease with a global prevalence 10.5% in 2021. Type 2 diabetes and insulin resistance remained one of the most adjustable risk factors for the development of dementia and AD, with a twofold increased risk of accelerated cognitive decline, dementia and cognitive impairment. Brain Derived Neurotrophic Factor (BDNF) is a key molecule posing survival and growth promoting actions on a variety of neurons, including hippocampal and cortical neurons, involved in plastic changes related to learning and memory. It plays a major role in synaptic plasticity, neuronal differentiation and survival, neuroprotection, and neuronal resilience and restoration against broad range of cellular insults. In addition, it has a key role in regulating axonal and dendritic growth and guidance, long-term potentiation (LTP) and participation in neurotransmitter release
AIM OF THE STUDY:
The present study aimed of comparing metformin and insulin use on cognitive status manifested by Mild cognitive impairment (MCI) using mini mental status examination (MMSE) and its relation to serum BDNF.
Keywords
Mild cognitive impairment (MCI); mini mental status examination (MMSE); Diabetes mellitus
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