Detection of Ceftriaxone antibiotic and removal via complexation with Fe (III)

Kamal El-dean, Adel M.; Tolba, Mahmoud S.; Galal, Mohamed S.; Al-Salahi, Najat O. A.; Hashem, Elham Y.

doi:10.21608/esugj.2022.138312.1008

	Detection of Ceftriaxone antibiotic and removal via complexation with Fe (III)
Egyptian Sugar Journal
Volume 18, Issue 0, June 2022, Page 53-59 PDF (600.73 K)
Document Type: Original Research Articles.
DOI: 10.21608/esugj.2022.138312.1008
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Authors
Adel M. Kamal El-dean¹; Mahmoud S. Tolba²; Mohamed S. Galal ³; Najat O. A. Al-Salahi^* ⁴; Elham Y. Hashem¹
¹Department of Chemistry, Faculty of Science, Assiut University, 71516 Assiut, Egypt
²Chemistry Department, Faculty of Science, New Valley University, 72511 Assiut, Egypt
³Department of Environmental Science and Pollution Treatment, Faculty of Sugar and Integrated Industries Technology, Assiut University, Egypt
⁴Upper Egypt Pharmaceuticals (UP Pharma), Industrial zone, Arab Al-Awamer, Assiut, Egypt
Abstract
Antibiotic pollution in the aquatic environment has emerged as one of the most serious concerns caused by the use of pharmaceuticals and personal care products (PPCPs). Antibiotic levels in wastewater from pharmaceutical factories and hospitals have been detected at varying levels. An effective method for the removal of ceftriaxone (a β-lactam antibiotic) in aqueous systems has been developed. The method uses Fe(III) to complex ceftriaxone and removes it from the solution. Ultraviolet (UV) and Fourier Transform Infra-Red (FTIR) detection techniques were used to identify the ceftriaxone-Fe(III) complex, while high-performance liquid chromatography (HPLC), was used to quantify the amount of ceftriaxone removed. Results showed that 99.7 % of ceftriaxone was removed in 3 h by Fe (III) ions in a 1:1 concentration ratio at pH 3.3 and at room temperature. The study demonstrated that reaction time, and concentration ratio of the reactants are critical parameters for effective complexation. The complexation reaction technique has the potential to be used in a treatment process for the removal of ceftriaxone chemically from industrial wastewater. However, a neutralization step is required to process the waste aqueous phase.
Keywords
Ceftriaxone; Ferric chloride; UV; FTIR; HPLC


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