An evaluation of the effects of ethosomes in the delivery of transdermal drugs
Gad, S., mousa, I., Hamadi, T., sayed, O. (2022). An evaluation of the effects of ethosomes in the delivery of transdermal drugs. EKB Journal Management System, 6(3), 120-127. doi: 10.21608/rpbs.2022.141371.1147
Shadeed Gad; ibrahim ahmed mousa; Taha Hamadi; Osama sayed. "An evaluation of the effects of ethosomes in the delivery of transdermal drugs". EKB Journal Management System, 6, 3, 2022, 120-127. doi: 10.21608/rpbs.2022.141371.1147
Gad, S., mousa, I., Hamadi, T., sayed, O. (2022). 'An evaluation of the effects of ethosomes in the delivery of transdermal drugs', EKB Journal Management System, 6(3), pp. 120-127. doi: 10.21608/rpbs.2022.141371.1147
Gad, S., mousa, I., Hamadi, T., sayed, O. An evaluation of the effects of ethosomes in the delivery of transdermal drugs. EKB Journal Management System, 2022; 6(3): 120-127. doi: 10.21608/rpbs.2022.141371.1147

An evaluation of the effects of ethosomes in the delivery of transdermal drugs

Records of Pharmaceutical and Biomedical Sciences
Article 9, Volume 6, Issue 3, April 2022, Page 120-127  XML PDF (580.29 K)
Document Type: Mini-reviews
DOI: 10.21608/rpbs.2022.141371.1147
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Authors
Shadeed Gad email orcid 1; ibrahim ahmed mousaorcid 2; Taha Hamadi3; Osama sayed4
1Faculty of Pharmacy - Suez Canal University
2General Authority of Health Care, Ismailia Governorate, Egypt.
3Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Suez Canal University
4Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Sinai University
Abstract
The purpose of drug administration through the skin is to treat skin disorders on a topical level or to deliver drugs to the systemic circulation via transdermal absorption due to the variability in peak plasma concentration following oral and parenteral delivery. Ethosomes lipid-based nanovesicles with improved softness, deformability, and elasticity, are the most investigated vesicular system. Ethanol, cholesterol, and lecithin are used to prepare ethosomes. The loose hair follicles and Stratum Corneum (SC) percutaneous route allowed the ethosomes to permeate the epidermis. During percutaneous penetration, the vesicles were released into the superficial layer of the skin, allowing the therapeutic substances to penetrate while the phospholipids remained in the upper epidermis.
Skin physiology, drug physicochemical factors, and the delivery system determine the frequency and degree of drug absorption through the skin. The present transdermal dosage forms, such as patches, ointments, and creams, are associated with several limitations. One of the most unpleasant side effects of transdermal patches is skin irritation, caused by their occlusive properties, which block sweat ducts, preventing water drainage from the skin surface. Other disadvantages include difficulties applying to curved surfaces, pain while peeling away, and a lack of aesthetic appeal
Keywords
Ethosomes; ethanol; skin; vesicles; Stratum Corneum
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