The effect of L–carnitine on gentamicin-induced nephrotoxicity and associated anaemia in adult male albino rats
Meky, N., Heibashy, M., Mahmoud, O., Youssef, H. (2015). The effect of L–carnitine on gentamicin-induced nephrotoxicity and associated anaemia in adult male albino rats. EKB Journal Management System, 32(part 2), 379-400. doi: 10.21608/jsrs.2015.24885
Nefissa Hussein Meky; Mohamed Islam Heibashy; Ola Mahmoud Mahmoud; Heba Abo Baker Youssef. "The effect of L–carnitine on gentamicin-induced nephrotoxicity and associated anaemia in adult male albino rats". EKB Journal Management System, 32, part 2, 2015, 379-400. doi: 10.21608/jsrs.2015.24885
Meky, N., Heibashy, M., Mahmoud, O., Youssef, H. (2015). 'The effect of L–carnitine on gentamicin-induced nephrotoxicity and associated anaemia in adult male albino rats', EKB Journal Management System, 32(part 2), pp. 379-400. doi: 10.21608/jsrs.2015.24885
Meky, N., Heibashy, M., Mahmoud, O., Youssef, H. The effect of L–carnitine on gentamicin-induced nephrotoxicity and associated anaemia in adult male albino rats. EKB Journal Management System, 2015; 32(part 2): 379-400. doi: 10.21608/jsrs.2015.24885

The effect of L–carnitine on gentamicin-induced nephrotoxicity and associated anaemia in adult male albino rats

Journal of Scientific Research in Science
Article 22, Volume 32, part 2, November 2015, Page 379-400  XML PDF (1.45 MB)
Document Type: Original Article
DOI: 10.21608/jsrs.2015.24885
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Authors
Nefissa Hussein Meky email 1; Mohamed Islam Heibashy2; Ola Mahmoud Mahmoud3; Heba Abo Baker Youssef4
1Zoology Department, Faculty of Science, Ain Shams University.
2Biological Applications Department Nuclear Research Centre, Atomic Energy Authority
3Departments of Hematology, Theodor Bilharz Research Institute, Cairo, Egypt
4Zoology Department, Women’s College, Ain Shams University.
Abstract
This study was conducted to evaluate the effect of L-carnitineon gentamicin-induced nephrotoxicity and anaemia in adult male albino rats. A control group (saline, group I, n = 21) was compared with rats administrated 80 mg/kg gentamicin, once daily for 10 days (groups II, n = 49). After 10 days 7 rats from each group were sacrificed for investigation. The remaining of normal control rats was served as normal control group (Group 1) (14 rats), while 42 nephrotoxic  rats  subdivide in to: Subgroup 2 (control 2): Nephrotoxic  rats (14 rats). Subgroup 3: Nephrotoxic rats were injected intraperitoneal with L-carnitine (300 mg/kg/day) for 15 and 30 days (14 rats). Subgroup 4: Nephrotoxic rats were injected intraperitoneal with L-carnitine (600 mg/kg/day) for 15and30 days (14 rats). At the end of each experiment period, 7 rats from each groups were sacrificed. The effect of L-carnitine (group III and IV) was compared. The activities of biochemical parameters [urea, creatinine, β2-microglobulin, potassium (K), total oxidant status (TOS)] and [iron (Fe), total iron binding capacity (TIBC) and ferritin] increased in nephrotoxic rats, while total protein, sodium (Na) and total antioxidant status (TAS) decreased and in haematological parameters osmotic fragility increased but haemoglobin and red blood cells (RBCs) decreased in nephrotoxic rats. Administration of L-carnitine improved alterations of biochemical and haematological parameters. In conclusion, this study demonstrated that treatment with L-carnitine attenuated the biochemical and haematological alterations induced by gentamicin and identifies new areas of research for development of better therapeutic agents for kidney and better dose.
 
Keywords
L-carnitine; gentamicin; Nephrotoxicity
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