Heterocyclization and Biological Evaluation of Malonic Hydrazide; Novel Synthesis of Some Azoles and Azines

Abd El-Azim, Mohamed H; assy, mohammed gomma; Elmesalamy, Maha Ahmed; Selim, Yasser

doi:10.21608/ejchem.2022.147813.6399

	Heterocyclization and Biological Evaluation of Malonic Hydrazide; Novel Synthesis of Some Azoles and Azines
Egyptian Journal of Chemistry
Volume 66, Issue 3, March 2023, Page 479-482 PDF (375.25 K)
Document Type: Review Articles
DOI: 10.21608/ejchem.2022.147813.6399
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Authors
Mohamed H Abd El-Azim¹; mohammed gomma assy²; Maha Ahmed Elmesalamy ³; Yasser Selim ⁴
¹Department of Chemistry, Faculty of Science, Zagazig University, Egypt.
²Department of Chemistry, Faculty of Science, Zagazig University, (Egypt)
³Department of Chemistry - Zagazig University - Zagazig- Egypt
⁴Chemistry Department, Faculty of Specific Education. Zagazig University
Abstract
Cyclocondensation of malonic hyrazide with two equimolar of dibenzal acetophenone 2 resulted in cyclohexane pyrazole 4 presumably via the non-isolable aza Michel product 3 followed by losing H2O. Three equivalent amount of benzoyl isothiocynate and malonic hydrazide undergo Michel and two Aza Michel addition providing poly thiourea derivative 6.The hydrazone type 7 cyclocondensed with two mole of CS2 to furnish pyridazine derivative 9. Nitrosation of target 7 resulted in hydrazone of type 11 that cyclized to oxadiazine 12. Compound 7 undergo Michel addition to hetero allene followed by cyclization yielding pyrimidine 15.
Keywords
Malonic hydrazide; azines; azoles; condensed system; polythiourea


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