PHTHALATE EXPOSURE AMONG EGYPTIAN SCHOOL CHILDREN IN RELATION TO ATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD)
mohamed, M., abdelsalam, M., zohairy, E., abdel-raof, N., aly, M., fakher, W. (2021). PHTHALATE EXPOSURE AMONG EGYPTIAN SCHOOL CHILDREN IN RELATION TO ATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD). EKB Journal Management System, 21(1), 139-148. doi: 10.21608/ejfsat.2020.24326.1127
marwa issak mohamed; Mervat HAMDY abdelsalam; eman zohairy; nada elsayed abdel-raof; mona mohamed aly; walaa fakher. "PHTHALATE EXPOSURE AMONG EGYPTIAN SCHOOL CHILDREN IN RELATION TO ATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD)". EKB Journal Management System, 21, 1, 2021, 139-148. doi: 10.21608/ejfsat.2020.24326.1127
mohamed, M., abdelsalam, M., zohairy, E., abdel-raof, N., aly, M., fakher, W. (2021). 'PHTHALATE EXPOSURE AMONG EGYPTIAN SCHOOL CHILDREN IN RELATION TO ATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD)', EKB Journal Management System, 21(1), pp. 139-148. doi: 10.21608/ejfsat.2020.24326.1127
mohamed, M., abdelsalam, M., zohairy, E., abdel-raof, N., aly, M., fakher, W. PHTHALATE EXPOSURE AMONG EGYPTIAN SCHOOL CHILDREN IN RELATION TO ATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD). EKB Journal Management System, 2021; 21(1): 139-148. doi: 10.21608/ejfsat.2020.24326.1127

PHTHALATE EXPOSURE AMONG EGYPTIAN SCHOOL CHILDREN IN RELATION TO ATTENTION DEFICIT HYPERACTIVITY DISORDER (ADHD)

The Egyptian Journal of Forensic Sciences and Applied Toxicology
Volume 21, Issue 1, March 2021, Page 139-148  XML PDF (425.63 K)
Document Type: Original Article
DOI: 10.21608/ejfsat.2020.24326.1127
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Authors
marwa issak mohamed email orcid 1; Mervat HAMDY abdelsalamorcid 2; eman zohairy3; nada elsayed abdel-raoforcid 4; mona mohamed alyorcid 3; walaa fakher5
1department of forensic and clinical toxicology cairo university
2department of forensic and clinical toxicology,faculty of medicine ,cairo university
3department of forensic medicine and clinical toxicology cairo university
4department of forensic medicine and clinical toxicology, faculty of medicine, cairo university
5psychiatry department faculty of medicine cairo university
Abstract
ABSTRACT
Background: Attention Deficit Hyperactivity Disorder (ADHD) is one of the most common neuropsychiatric disorders of childhood. Phthalates are industrial chemicals often used in personal care products and to soften plastics in toys and household items such as food containers, and medical devices. Animal studies have reported that the phthalate compound might cause hyperactivity and impulsivity in rats. However, the relation between phthalates and ADHD in human is still controversial. The aim of our study is to investigate the possible association between urinary phthalate metabolite levels and attention deficit disorder, learning disability in 6–12-years old children. Methods: Urine samples were obtained from 80 children. All children were selected from the attendants of Abu Elreesh child psychiatry outpatient clinic, Cairo University. subjects were divided into two main groups Group A (patients) consisted of 50 children with Attention-deficit/hyperactivity disorder (ADHD) diagnosed by psychiatric consultant and Group B (control) consisted of 30 normal children. In urine, mono butyl phthalate (MBP) metabolite were measured with high performance liquid chromatography (HPLC). Results: The mean concentration of MBP level was (15.539±8.316) for patients (group A) and (8.085 ±2.426) for controls (group B) with significant difference between groups. Also, there was significant correlation with processing milk, plastic containers, toys, cosmetics, wall, and floor materials containing phthalate exposure and higher level of (MBP) in urine of group A. Conclusion: The present study showed association between phthalate metabolites in urine and symptoms of ADHD among school-age children
Keywords
Attention deficit/hyperactivity disorder (ADHD); Learning disability; Phthalates; Plasticizers
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