Synthesis of New Organophosphorus Pyrazole Derivatives as Human Myeloblastic Leukemia HL60 Cytotoxic Agents
Ali, M., El-Gendy, M. (2022). Synthesis of New Organophosphorus Pyrazole Derivatives as Human Myeloblastic Leukemia HL60 Cytotoxic Agents. EKB Journal Management System, 65(12), 27-37. doi: 10.21608/ejchem.2022.150667.6525
Mansoura Ali; Mohamed El-Gendy. "Synthesis of New Organophosphorus Pyrazole Derivatives as Human Myeloblastic Leukemia HL60 Cytotoxic Agents". EKB Journal Management System, 65, 12, 2022, 27-37. doi: 10.21608/ejchem.2022.150667.6525
Ali, M., El-Gendy, M. (2022). 'Synthesis of New Organophosphorus Pyrazole Derivatives as Human Myeloblastic Leukemia HL60 Cytotoxic Agents', EKB Journal Management System, 65(12), pp. 27-37. doi: 10.21608/ejchem.2022.150667.6525
Ali, M., El-Gendy, M. Synthesis of New Organophosphorus Pyrazole Derivatives as Human Myeloblastic Leukemia HL60 Cytotoxic Agents. EKB Journal Management System, 2022; 65(12): 27-37. doi: 10.21608/ejchem.2022.150667.6525

Synthesis of New Organophosphorus Pyrazole Derivatives as Human Myeloblastic Leukemia HL60 Cytotoxic Agents

Egyptian Journal of Chemistry
Article 4, Volume 65, Issue 12, December 2022, Page 27-37  XML PDF (960.34 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2022.150667.6525
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Authors
Mansoura Ali email 1; Mohamed El-Gendyorcid 2
1National Research Centre,Dept. of Organometallic and Organometalloid Chemisry
2Drug Bioassay-Cell Culture Laboratory, Pharmacognosy Department, Pharmaceutical and Drug Industries Research Institute, National Research Centr
Abstract
Hexaphenylcarbodiphosphorane reacted with oxobutenyl-, and oxophenylpropenyl-pyrazolones to give oxaphosphinin, triphenylphosphaneylidenecyclobutenyl, (triphenylphosphaneylidene)-butadienyl and triphenyldihydrophosphetyl derivatives. Triphenylphosphane and triphenylphosphane oxide were also isolated and identified. Moreover, Japanese reagent reacted with the same pyrazolones to afford sulfido-oxathiaphosphinin products. Possible reaction mechanisms were considered and structured elucidations for the new products were based upon compatible microanalytical and spectroscopic measurements. Four newly synthesized compounds showed promising cytotoxicity against human myeloblastic leukemia HL60 cells with selectivity towards tumor cells when compared to non-tumor human fibroblasts BJ cells.
Keywords
phosphallene; bis-ylide; oxaphosphinin; Japanese reagent; myeloblastic leukemia
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