Study of Serum Level of L-Carnitine in Children with Non-Syndromic Autism Spectrum Disorder: A Biological Metabolic Marker | ||||
Suez Canal University Medical Journal | ||||
Article 10, Volume 25, Issue 2, July 2022, Page 77-86 PDF (344.56 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/scumj.2022.251408 | ||||
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Authors | ||||
Shimaa A.M. Anwar 1; Hussein H. Abdeldayem1; Magdy M. El-Bordiny2; Maha S. Kamel3 | ||||
1Department of Pediatrics, Faculty of Medicine, Alexandria University, Egypt | ||||
2Department of Clinical and Chemical Pathology, Faculty of Medicine, Alexandria University, Egypt | ||||
3Department of Pediatrics, Ministry of Health, Alexandria, Egypt | ||||
Abstract | ||||
Background: Autism Spectrum Disease (ASD) is a complex developmental disorder. Children with autism spectrum disorder have low serum levels of L-carnitine. Aim:We aimed at assessing the reliability of using the serum level of L-carnitine as a biomarker in children with ASD. Subjects and Methods: This is a case-control study conducted on 60 children at the outpatient Neurobehavioral Clinic of Alexandria University Children’s Hospital (AUCH), divided into 2 groups. Group 1 (research group): 30 children diagnosed with ASD and Group 2 (control group): 30 healthy children. Children of both groups were subjected to history taking, clinical neurological examination, Childhood autism rating scale (CARS), and serum carnitine level measurement. Results: The mean serum level of L-carnitine in children with ASD was significantly lower in cases than in control children. No statistically significant correlation between low levels of serum L-carnitine and gender was detected in the patients’ group. The severity of ASD symptoms had a non-significant correlation with levels of L- carnitine. Conclusion: Serum L-carnitine can be considered a biochemical metabolic marker for mitochondrial dysfunction in children with ASD. | ||||
Keywords | ||||
CARS; Biological marker; ASD; mitochondrial dysfunction; repetitive behavior | ||||
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