Extracts of Turmeric (Curcuma longa L.) as a Potential ‎Biocontrol of Multidrug-Resistant‏ ‏Acinetobacter baumannii
abdelsamie, A., Afifi, M., Salem, W., Elshenawy, F. (2022). Extracts of Turmeric (Curcuma longa L.) as a Potential ‎Biocontrol of Multidrug-Resistant‏ ‏Acinetobacter baumannii. EKB Journal Management System, 26(1), 17-28. doi: 10.21608/jesj.2022.140793.1015
Abdelhamed abdelsamie; Magdy Mohamed Afifi; Wesam mohamed Ali Salem; Fareed Elshenawy. "Extracts of Turmeric (Curcuma longa L.) as a Potential ‎Biocontrol of Multidrug-Resistant‏ ‏Acinetobacter baumannii". EKB Journal Management System, 26, 1, 2022, 17-28. doi: 10.21608/jesj.2022.140793.1015
abdelsamie, A., Afifi, M., Salem, W., Elshenawy, F. (2022). 'Extracts of Turmeric (Curcuma longa L.) as a Potential ‎Biocontrol of Multidrug-Resistant‏ ‏Acinetobacter baumannii', EKB Journal Management System, 26(1), pp. 17-28. doi: 10.21608/jesj.2022.140793.1015
abdelsamie, A., Afifi, M., Salem, W., Elshenawy, F. Extracts of Turmeric (Curcuma longa L.) as a Potential ‎Biocontrol of Multidrug-Resistant‏ ‏Acinetobacter baumannii. EKB Journal Management System, 2022; 26(1): 17-28. doi: 10.21608/jesj.2022.140793.1015

Extracts of Turmeric (Curcuma longa L.) as a Potential ‎Biocontrol of Multidrug-Resistant‏ ‏Acinetobacter baumannii

Journal of Environmental Studies
Volume 26, Issue 1, June 2022, Page 17-28  XML PDF (916.06 K)
Document Type: High quality original papers
DOI: 10.21608/jesj.2022.140793.1015
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Authors
Abdelhamed abdelsamie email orcid 1; Magdy Mohamed Afifi1; Wesam mohamed Ali Salem2; Fareed Elshenawy1
1Department of Botany and Microbiology, Faculty of Science, Al-Azhar University, Assuit 71524, Egypt
2Department of Botany and Microbiology, Faculty of Science, South Valley University, Qena 83523, Egypt
Abstract
Nosocomial infections with Acinetobacter baumannii are increasing every day, making treatment with traditional antibiotics more complicated. This work aimed to investigate the antibacterial activity of Curcuma longa extracts against carbapenem-resistant isolates of A. baumannii. A  total of  90 samples (Sputum, n=40 and Urine, n=50) were collected and biochemically identified via Vitek -2 system. Ten isolates were identified as A. baumannii (10/90; 11.1%). (10/90; 100 %) of isolates identified were multi drug resistance (MDR). Curcuma longa  extracts aqueous and/or ethyl acetate of, exhibited a significant MBC value varying from 43.75 to 50.83 mg ml-1 against A. baumannii isolates (A1, A2, A3, A5, A6, and A8), respectively. Within isolates A1 and A8, ethanol extracts revealed MBC with significant values (30 to 70 mg ml-1) respectively. The main phytochemical compounds detected among 68 bioactive compounds in the extracts of C. longa over the GC- mass spectra analysis were Turmerone (59.42%), Beta-caryophyllene (16.66 %), Caryophyllene oxide (15.62 %), Isolongifol (12.14 %), Alpha-pinene (12.07 %), Citral (11.68 %), Curdione (11.0 %), B -Sesquiphellandrene (10.47% ), B-myrcene (8.12 %), D-Limonene (8.04 %). Bactericidal activity of C. longa against MDR A. baumannii were supported by phytochemical compounds that detected in GC-MS analysis.
Keywords
Acinetobacter baumannii; Curcuma longa; GC-Mass; Imipenem
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