Study for registry and clinical spectrum of bone marrow failure in pediatrics; single centre experience
Abd Elrahman, A., Meabed, M., Abd Elkareem, R., Mohamed, Y. (2022). Study for registry and clinical spectrum of bone marrow failure in pediatrics; single centre experience. EKB Journal Management System, 3(3), 17-27. doi: 10.21608/ejmr.2022.251503
Asmaa Thabet Abd Elrahman; Mohamed Hussien Meabed; Rehab Muhamed Abd Elkareem; Yasmine Awadallh Mohamed. "Study for registry and clinical spectrum of bone marrow failure in pediatrics; single centre experience". EKB Journal Management System, 3, 3, 2022, 17-27. doi: 10.21608/ejmr.2022.251503
Abd Elrahman, A., Meabed, M., Abd Elkareem, R., Mohamed, Y. (2022). 'Study for registry and clinical spectrum of bone marrow failure in pediatrics; single centre experience', EKB Journal Management System, 3(3), pp. 17-27. doi: 10.21608/ejmr.2022.251503
Abd Elrahman, A., Meabed, M., Abd Elkareem, R., Mohamed, Y. Study for registry and clinical spectrum of bone marrow failure in pediatrics; single centre experience. EKB Journal Management System, 2022; 3(3): 17-27. doi: 10.21608/ejmr.2022.251503

Study for registry and clinical spectrum of bone marrow failure in pediatrics; single centre experience

Egyptian Journal of Medical Research
Volume 3, Issue 3, July 2022, Page 17-27  XML PDF (414.89 K)
Document Type: Original Article
DOI: 10.21608/ejmr.2022.251503
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Authors
Asmaa Thabet Abd Elrahman1; Mohamed Hussien Meabedorcid 1; Rehab Muhamed Abd Elkareem2; Yasmine Awadallh Mohamed1
1Depatrement of Pediatrics, Faculty of Medicine, Beni-Suef Univeristy, Egypt
2Depatrement of Clinical and Chemical Pathology, Faculty of Medicine, Beni-Suef University, Egypt.
Abstract
Background: Bone marrow failure is a group of disorders characterized by the inability of bone marrow to produce sufficient blood cells. They can be divided into inherited disorders, acquired disorders and diseases infiltrating bone marrow. Acute leukemia is a serious cause of bone marrow failure which  needs early diagnosis and management . Purpose: To study for   registry,  and clinical spectrum of bone marrow failure in Beni-Suef university hospital to detect the magnitude of the problem . Patients and methods: It is  cross sectional study over a period of six months from January 2019 to June 2019, in which patients with bone marrow failure (monocytopenia, bicytopenia or pancytopenia) from  pediatric age group (0-13 years) who were admitted in the pediatric department in Beni-Suef university hospital were included and followed up. They were subjected to a detailed history, full examination and laboratory investigation; complete blood count, reticulocyte cont, bone marrow aspirate & biopsy,  virology study and accordingly other investigations were done such as flow cytometry for cd55 & cd59, glucocerebrosidase enzyme assay, chromosomal breakage analysis and imaging. Results: Out of 22000 outpatients and 1700 inpatients,55 patients had diagnosed as bone marrow failure during six months duration with percentage of o.23%. The most frequent diagnosis of bone marrow failure was acute Leukemia (30.9 %), followed by Idiopathic aplastic anemia (27.3%) then Fanconi anaemia (21.8%). Conclusion: Bone marrow failure is not rare ,acute Leukemia should be considered strongly in the diagnosis of any case of bone marrow failure.
Keywords
Bone marrow failure; acute Leukemia; Beni-Suef
References
  1. Zhang L: Inherited and acquired bone marrow failure syndromes in the era of gene sequencing, J. Leuk 2016; 4(4): e119.
  2. Alter BP, Giri N, Savage SA, Peters JA, Loud JT, Leathwood L, Carr AG, Greene MH, Rosenberg PS.:Malignancies and survival patterns in the National Cancer Institute inherited bone marrow failure syndromes cohort study. Br J Haematol. 2010;150(2):179-88.
  3. Katherine A: Comprehensive Pediatric Hospital Medicine, in book. 2007; pp.738-743.
  4. Moore CA, Krishnan K. :Bone Marrow FailureIn: StatPearls Publishing. Jan 2019.
  5. Shimamura A and Alter B :Pathophysiology and management of inherited bone marrow failure syndromes. J.bl rev 2010; 24(3)101-122.
  6. Calado R.T,Cle D.v :Treatment of inherited bone marrow failure syndromes beyond transplantation Hematol ogy Am Soc Hematol Educ Program. 2017; (1):96-101.
  7. :Inherited bone marrow failure syndromes.TomVulliamyHaematologica. 2010; 95 (8) 1236-1240; Aug.
  8. Fatih M Azik , Talia ILERI,etal,:Fanconi anemia:29 years in a single center, International J Hematol oncol.2010;4(20).
  9. Pahloosye A,Hashemi A,etal:presenting Clinical and Laboratory data of Childhood acute lymphoblastic leukemia,Iran J Ped Hematol Oncol.(2011);1(3):71-77.
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