Interleukin-17 Serum Level and Its Prognostic Significance in Children with Immune Thrombocytopenia | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 233, Volume 88, Issue 1, July 2022, Page 3733-3736 PDF (293.18 K) | ||||
| DOI: 10.21608/ejhm.2022.251657 | ||||
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| Authors | ||||
| Tamer Hasan Moustafa Hassan1; Mohamed Mohamed Abdel Salam2; Asmaa Diaa Eldin Ali Abdeen* 1; Nermin Raafat Abdel Fattah1 | ||||
| 1Departments of 1Pediatrics | ||||
| 22Medical Biochemistry, Faculty of Medicine, Zagazig University, Zagazig, Egypt. | ||||
| Abstract | ||||
| Background: Immune thrombocytopenia (ITP) is an acquired hematological disorder that is developed secondary to the production of auto-antibodies against platelets leading to isolated thrombocytopenia, in the absence of other causes of thrombocytopenia such as drugs, infections, malignancy, or other autoimmune diseases. Objective: This study aimed to determine serum levels of IL-17 and evaluate its prognostic significance in children with immune thrombocytopenia. Subjects and methods: A case control study carried out in Pediatric Hematology Outpatient Clinic, Zagazig University Hospitals during the period from September 2019 to August 2020. It included 100 subjects who were divided into 2 group; 50 children with ITP and 50 age and sex matched healthy children as a control group. Results: In this study, newly diagnosed patients with ITP had significantly higher levels of IL-17 compared to persistent and chronic patients with ITP (554.3, 259.9 and 158.6 pg/ml in in newly diagnosed ITP, persistent ITP and chronic ITP respectively, p < 0.001). Conclusion: We concluded that serum IL-17 predicts susceptibility to ITP in Egyptian children with ITP. | ||||
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