Association of Vitamin D Receptor Gene (FokI) (rs2228750) Polymorphism with Susceptibility to Tuberculosis
El-Shimi, O., Abdel Samea, S., Samy, N., Fayed, S. (2020). Association of Vitamin D Receptor Gene (FokI) (rs2228750) Polymorphism with Susceptibility to Tuberculosis. EKB Journal Management System, 29(4), 75-81. doi: DOI:https://doi.org/10.51429/EJMM29410
Ola S. El-Shimi; Soheir A. Abdel Samea; Nahla M. Samy; Sahar M. Fayed. "Association of Vitamin D Receptor Gene (FokI) (rs2228750) Polymorphism with Susceptibility to Tuberculosis". EKB Journal Management System, 29, 4, 2020, 75-81. doi: DOI:https://doi.org/10.51429/EJMM29410
El-Shimi, O., Abdel Samea, S., Samy, N., Fayed, S. (2020). 'Association of Vitamin D Receptor Gene (FokI) (rs2228750) Polymorphism with Susceptibility to Tuberculosis', EKB Journal Management System, 29(4), pp. 75-81. doi: DOI:https://doi.org/10.51429/EJMM29410
El-Shimi, O., Abdel Samea, S., Samy, N., Fayed, S. Association of Vitamin D Receptor Gene (FokI) (rs2228750) Polymorphism with Susceptibility to Tuberculosis. EKB Journal Management System, 2020; 29(4): 75-81. doi: DOI:https://doi.org/10.51429/EJMM29410

Association of Vitamin D Receptor Gene (FokI) (rs2228750) Polymorphism with Susceptibility to Tuberculosis

Egyptian Journal of Medical Microbiology
Volume 29, Issue 4, October 2020, Page 75-81  XML PDF (397.56 K)
Document Type: New and original researches in the field of Microbiology.
DOI: DOI:https://doi.org/10.51429/EJMM29410
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Authors
Ola S. El-Shimi* 1; Soheir A. Abdel Samea1; Nahla M. Samy2; Sahar M. Fayed1
1Clinical & Chemical Pathology Department, Faculty of Medicine, Benha University, Egypt
2MBBCh, Faculty of Medicine, Tanta University, Egypt
Abstract
Background: Genetic susceptibility has been suggested as an important explanation for individual risk for tuberculosis. The association between vitamin D receptor (VDR) FokI gene polymorphisms and the risk of tuberculosis have been studied in several populations; but results were inconsistent. Objectives: This study aimed to determine the influence of vitamin D status and frequency of association of VDR FokI (rs2228570) polymorphism on susceptibility to pulmonary tuberculosis. Methodology: A case-control study was conducted between 40 pulmonary tuberculosis patients and 40 control subjects. Serum vitamin D level and VDR FokI gene (rs2228570) polymorphism were tested. Results: Tuberculosis patients had significant lower vitamin D level compared to controls (P = 0.002). Patients showed significantly higher frequencies of VDR FokI (rs2228750) Ff, ff genotypes and f allele than controls (P = 0.023, 0.014, <0.001 respectively) with significant lower vitamin D level in patients with ff compared to patients with FF or Ff genotypes (P = 0.017). Excess smoking, vitamin D insufficiency and VDR FokI (rs2228750) (Ff+ff) genotypes were found predictors for susceptibility to tuberculosis infection. Conclusion: vitamin D deficiency plays a role as a risk factor for tuberculosis and VDR FokI (rs2228750) polymorphism may be partially responsible for host susceptibility to human tuberculosis in Egyptians.
Keywords
Tuberculosis; susceptibility; VDR; FokI gene; Egypt
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