Effect of MCP-1 and CCR2 Genes Polymorphism on Development of Hepatocellular Carcinoma in HCV- Infected Patients in Sohag Governorate, Egypt
Nasr El-Din, A., Galal, G., Abudeif, A., Hashem, M., Sheneef, A. (2020). Effect of MCP-1 and CCR2 Genes Polymorphism on Development of Hepatocellular Carcinoma in HCV- Infected Patients in Sohag Governorate, Egypt. EKB Journal Management System, 29(4), 125-134. doi: DOI:https://doi.org/10.51429/EJMM29416
Asmaa Nasr El-Din; Ghada M. Galal; Ahmed Abudeif; Marwa S. Hashem; Abeer Sheneef. "Effect of MCP-1 and CCR2 Genes Polymorphism on Development of Hepatocellular Carcinoma in HCV- Infected Patients in Sohag Governorate, Egypt". EKB Journal Management System, 29, 4, 2020, 125-134. doi: DOI:https://doi.org/10.51429/EJMM29416
Nasr El-Din, A., Galal, G., Abudeif, A., Hashem, M., Sheneef, A. (2020). 'Effect of MCP-1 and CCR2 Genes Polymorphism on Development of Hepatocellular Carcinoma in HCV- Infected Patients in Sohag Governorate, Egypt', EKB Journal Management System, 29(4), pp. 125-134. doi: DOI:https://doi.org/10.51429/EJMM29416
Nasr El-Din, A., Galal, G., Abudeif, A., Hashem, M., Sheneef, A. Effect of MCP-1 and CCR2 Genes Polymorphism on Development of Hepatocellular Carcinoma in HCV- Infected Patients in Sohag Governorate, Egypt. EKB Journal Management System, 2020; 29(4): 125-134. doi: DOI:https://doi.org/10.51429/EJMM29416

Effect of MCP-1 and CCR2 Genes Polymorphism on Development of Hepatocellular Carcinoma in HCV- Infected Patients in Sohag Governorate, Egypt

Egyptian Journal of Medical Microbiology
Volume 29, Issue 4, October 2020, Page 125-134  XML PDF (467.88 K)
Document Type: New and original researches in the field of Microbiology.
DOI: DOI:https://doi.org/10.51429/EJMM29416
View on SCiNiTO View on SCiNiTO
Authors
Asmaa Nasr El-Din email 1; Ghada M. Galal2; Ahmed Abudeif2; Marwa S. Hashem3; Abeer Sheneef1
1Departments of Medical Microbiology and immunology, Faculty of Medicine, Sohag University
2Tropical Medicine and Gastroenterology, Faculty of Medicine, Sohag University
3Biochemistry, Faculty of Medicine, Sohag University
Abstract
Background: HCC is the most common primary tumor of the liver .It is the fifth common cancer in men and the eighth common in women and is the second leading cause of cancer-related death in the world. The MCP-1 is a chemokine and a potent chemotactic factor for monocytes. MCP-1 expression in tumor cells is significantly linked to the extent of tumor-associated macrophage infiltration. Objectives: to detect the effect of MCP-1 and CCR2 Genes Polymorphism in development of HCC in HCV- related liver cirrhosis patients. Methodology: MCP-1-2518 A/G and CCR2 (V64Ile) genes polymorphism was assessed by real time PCR in 35 HCC patients and 30 HCV related LC. Serum MCP-1 was measured by ELISA. Results: For MCP-1 -2518 A G gene, HCC patients had a higher frequency of AG and GG genotypes than of AA genotype compared to other groups. For CCR2 (V64Ile), HCC patients had a higher frequency of GA and AA genotypes than GG genotype compared to other groups. Conclusion: There is a significant association between CCR2 (V64Ile) polymorphism, high serum MCP-1 level and HCC development in HCV- related liver cirrhosis patients.
Keywords
HCC; MCP-1 -2518 A/G; CCR2 (V64Ile) genotypes; SNP
Statistics
Article View: 91
PDF Download: 80