Role of High Mobility Group Box1 in Pathogenesis of Hepatitis C Virus induced Hepatocellular Carcinoma

Samra, Nouran E.; El-Etreby, Shahira; Mahdy, Rasha H. El-; El-Kazzaz, Samah S.; El-Nashar, Nariman M.

doi:DOI:https://doi.org/10.51429/EJMM29417

	Role of High Mobility Group Box1 in Pathogenesis of Hepatitis C Virus induced Hepatocellular Carcinoma
Egyptian Journal of Medical Microbiology
Volume 29, Issue 4, October 2020, Page 135-141 PDF (562.53 K)
Document Type: Review articles
DOI: DOI:https://doi.org/10.51429/EJMM29417
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Authors
Nouran E. Samra ¹; Shahira El-Etreby²; Rasha H. El- Mahdy¹; Samah S. El-Kazzaz¹; Nariman M. El-Nashar¹
¹Department of Medical Microbiology and Immunology, Faculty of Medicine, Mansoura University
²Hepatology & Gastroenterology unit, Faculty of Medicine, Mansoura University
Abstract
Hepatocellular carcinoma "HCC" is a leading cause of cancer mortality worldwide. High-mobility group box 1 "HMGB1" is a nuclear DNA-binding protein which involved in DNA stability, programmed cell death, immune response and inflammatory responses in HCV and HCC. Its over expression was revealed in HCC and different types of human cancers.
Keywords
HMGB1; HCV; HCC; Cancer; HMGB1 receptors


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