COPPER NITRATE TRIHYDRATE CATALYZED EFFICIENT ONE POT SYNTHESIS OF AMIDOALKYLNAPHTHOL DERIVATIVES. | ||||
| Al-Azhar Bulletin of Science | ||||
| Article 6, Volume 25, Issue 1-A, June 2014, Page 45-50 PDF (117.66 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/absb.2014.25181 | ||||
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| Authors | ||||
| A A. NASREEN* ; RITA M. BORIK | ||||
| Department of Chemistry, College of Sciences (Girls), Jazan University, Jazan , Saudi Arabia | ||||
| Abstract | ||||
| In the present study we extend the scope of the Cu(NO3)2.3H2O catalyzed synthesis of amido alkyl naphthols and the results are presented here. In order to optimize the reaction conditions initially we studied the efficacy of Cu(NO3)2.3H2O by taking catalytic amount of 10 mol% and benzaldehyde (1 mmol) -naphthol (1 mmol) and acetamide (1.2 mmol) in acetonitrile (10 ml) as model reaction.We have developed a practical and new, general efficient procedure for the one pot synthesis of amidoalkyl naphthols by coupling of various aromatic aldehydes with amides urea and -naphthol using Cu(NO3)2.3H2O as catalyst. The present protocol has several advantages of readily available, inexpensive catalyst, mild reaction conditions, easy handling, excellent yields, greater selectivity, operational and experimental simplicity. We believe that Cu(NO3)2.3H2O catalyzed methodology will definitely be a valuable addition to the existing process in the field of amidoalkyl naphthols. | ||||
| Keywords | ||||
| Amidoalkyl naphthols; -naphthol; Multi component reaction; Cu(NO3)2.3H2O | ||||
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