Evaluation of the antioxidant and Anti-inflammatory Activities of Moringa oleifera Lam Extracts and Determination of Their Active Components | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 66, Issue 7, July 2023, Page 479-486 PDF (296.64 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2022.147344.6387 | ||||
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| Authors | ||||
Sundus Hameed Ahmed  1; Hadeel Esam Hassan2; Ferial Majed Mahdi3
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| 1College of Science, MUSTANSIRIYAH University, Baghdad, Iraq | ||||
| 2Biology Department, College of Science, Mustansiriyah University, Baghdad, Iraq | ||||
| 3Veterinary medicines Department, Industrial Research and Development, Ministry of Industry and Minerals | ||||
| Abstract | ||||
| Background: Natural products are attracting the attention of researchers due to their widespread use in pharmaceutical industries. Moringa oleifera is one of these plants with bioactivity and is used as an antioxidant. Objective: The current research was conducted to assess the anti-inflammatory and antioxidant efficacies of various Moringa leaf extracts and determine their active components. Materials and Methods: Different solvents (cold water, hot water, 70% ethanol, cold ethanol, and hot ethanol) were utilized to extract M. oleifera. The extracts were then analyzed with FTIR to determine the percentage of active compounds in each extract. Stabilization of the red blood cell membrane, denaturation protein inhibition, and antioxidant potential of the extracts were determined. Results: The FTIR analysis revealed the active components in the various extracts to be phenol compounds, as evidenced by a specific peak in certain regions. The hot ethanolic extract was found to have the highest amount of bioactive compound (89.33%) compared to other extracts. Also, the same extract had the highest activity in stabilizing red blood cells, protein inhibition, as well as radical scavenging. Conclusion: The findings of this investigation indicate that the hot ethanolic extract of M. oleifera is more effective in all the test activities compared to the other extracts. | ||||
| Keywords | ||||
| Antioxidant; Moringa oleifera; TPC; Protein denaturation; FTIR; RBCs membrane stabilization | ||||
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