BMI and Fasting blood glucose in Acne vulgaris | ||||
| Benha Journal of Applied Sciences | ||||
| Article 10, Volume 7, Issue 6, June 2022, Page 77-84 PDF (1007.03 K) | ||||
| Document Type: Original Research Papers | ||||
| DOI: 10.21608/bjas.2022.252189 | ||||
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| Authors | ||||
| K M.AL-Balwa1; M Z.Kenawy2; R M.Salem2; A A.EL-Fallah3 | ||||
| 1M.B, B. Ch, Al-Anbar University-Iraq /2012 | ||||
| 2Dermatology, Venereology and Andrology,Dept., Faculty of Medicine, Benha Univ., Benha, Egypt | ||||
| 3Clinical and Chemical Pathology ,Dept., Faculty of Medicine, Benha Univ., Benha, Egypt | ||||
| Abstract | ||||
| Acne vulgaris, the most prevalent inflammatory condition of the pilosebaceous unit, is characterised by comedones, papules, pustules, nodules, and pseudocysts, as well as a variety of other lesions. Most often affecting the face (93.30 percent) but also the chest (50 percent) and the back (both 50 percent), acne may occur as non-inflammatory or inflammatory lesions, or as a combination of the two (41.7 percent ). Scars were seen in 65 percent of the patients, and PIH was found in 75 percent. Since 35% of patients tested responded positively to stress as a risk factor for acne vulgaris, it's possible that stress plays a role in the development of acne vulgaris. Analyzing the BMI and fasting blood glucose levels of acne vulgaris patients was the goal of this study, which correlated them with disease severity. Patients were separated into three groups (mild, moderate, and severe acne vulgaris) with a total of 60 patients in each of the three categories. A second group of 60 people, all of whom seemed to be in good health, served as a control. Patients from Benha University Hospitals' outpatient clinic for dermatology, andrology and venereal disease were included from July 2021 to February 2022 for the study. Results: Patients' IR, HOMA1-IR, fasting glucose, fasting insulin, and IR were all considerably higher in the patients than they were in the control participants. The patient group had considerably lower HOMA1-percent S and QUICKI scores than the control group. Severe acne vulgaris had substantially higher serum mean FG, FI, HOMA2-IR, and HOMA1-IR values than mild or moderate groups, but serum mean adipsin and QUICKI values were lower in the severe and moderate groups. FG, FI, IR, and HOMA1-IR were considerably greater in severe acne vulgaris compared to mild and moderate severity groups, but adipsin and QUICKI were significantly lower than their counterparts in the mild and moderate groups in the saliva. BMI, FG, FI, HOMA2-IR, and HOMA1-IR all had negative relationships with serum adipsin. GAGS, HOMA1-percent S, DI, and QUICKI were all shown to have a positive correlation with it. There was a negative correlation between BMI, GAGS, Ir and HOMA1-Ir, and a positive correlation between FG and FI with adiponectin in the salivary glands. The AUCs for serum adipsin, salivary adipsin, and QUICKI were 0.992, 0.877, and 0.711, respectively, while the cut-off values were 3178, 344.5, and 0.325 when distinguishing between steady and exacerbation patients. FBG was shown to have a positive correlation with BMI in terms of serum parameters. There was no connection between BMI and FG in terms of salivary markers. Adipsin levels in the blood and salivary glands may both be utilised to distinguish acne vulgaris patients from healthy controls when predicting the development of acne vulgaris in such people | ||||
| Keywords | ||||
| Adipsin; Insulin Resistance; Acne Vulgaris | ||||
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