Diagnostic Accuracy of IL-17A/IL-17F Gene Polymorphism and Anti-Carbamylated Protein Antibody for Rheumatoid Arthritis: Meta-analysis Study (2014-2020) | ||||
| SVU-International Journal of Medical Sciences | ||||
| Article 11, Volume 6, Issue 1, January 2023, Page 89-101 PDF (244.08 K) | ||||
| Document Type: Reviews Articles. | ||||
| DOI: 10.21608/svuijm.2022.146355.1329 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Samar Sayed Ahmed  1; Mostafa I. El-Amir2; Mohamed Ali El-Feky3; Eman Ragab Abdelradi4
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| 1Medical Microbiology and Immunology, Faculty of Medicine, South Valley University , Qena , Egypt | ||||
| 2Department of Medical Microbiology and Immunology, Faculty of Medicine, South Valley University,Qena, Egypt | ||||
| 3Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University,Assiut, Egypt | ||||
| 4Physical Medicine, Rheumatology & Rehablitition Department ,Faculty of medicine, South Valley University ,Qena ,Egypt. | ||||
| Abstract | ||||
| Background: The anti-CarP antibody is a novel biomarker that might help in the diagnosis of rheumatoid arthritis. Also, the associations between Interleukin-17A and17F gene polymorphism with inflammatory arthritis were inconsistent among previous studies. Objectives: to evaluate the diagnostic value of the anti-CarP antibody for RA and to determine the relation between IL-17F and IL-17A gene polymorphism with rheumatoid arthritis. Methods: A literature review of PubMed, PsycINFO, BioMed Central and Medline databases was carried out to identify peer reviewed peer reviewed studies, published between 2014 and 2020. Results: Fifteen studies were included in total and the pooled sensitivity, specificity, and positive and negative likelihood ratios for anti-CarP antibody were 42% (95% CI, 38% to 45%), 96% (95% CI, 95% to 97%), 10.2 (95% CI, 7.5 to 13.9), and 0.61 (95% CI, 0.57 to 0.65), respectively. The synopsis diagnostic odds ratio was 17 (95% CI, 12 to 24), and the area under summary receiver operator characteristic curve was 80% (95% CI, 77% to 84%). Further, there were significant associations between IL-17rs2275913 G allele with OA, RA susceptibility (P < 0.05) but not AS. A significant association between rs763780 and RA susceptibility was detected in Caucasian populations (P < 0.05). Conclusion: The moderate value of Anti-CarP antibody in the diagnosis of RA is relatively low sensitivity and high specificity. As well, IL-17F gene rs763780 C allele confers the increasing in possibility of inflammatory arthritis. | ||||
| Keywords | ||||
| Accuracy; IL-17A/IL-17F; Anti-CarP Antibody; Gene polymorphism; Rheumatoid Arthritis; Meta-analysis Study | ||||
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