Study of Plasma Protein Z level in Neonates with Respiratory Distress Syndrome Compared with Healthy Neonates | ||||
| Benha Medical Journal | ||||
| Article 4, Volume 39, Issue 3, November and December 2022, Page 805-816 PDF (724.88 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bmfj.2022.140246.1597 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Iman Aly1; Amira Abdelrahman2; Omnia Gamal Montaser  3; Neveen Abed1
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| 1Pediatric department, Faculty of Medicine – Benha University | ||||
| 2Clinical & Chemical Pathology, Faculty of Medicine – Banha University, | ||||
| 3pediatric department Benha faculty of medicin Benha university | ||||
| Abstract | ||||
| Background: Data on Protein Z (PZ) level may be useful in neonatal respiratory distress syndrome (RDS) as in RDS the defect in both coagulation and fibrinolytic system may play a role in the pathogenesis and progression of the disease. Aim: To evaluate plasma protein Z levels in neonatal respiratory distress syndrome. Methods: This study was performed on 40`neonates diagnosed with respiratory distress syndrome and 40 age and sex matched apparently healthy neonates as controls. Plasma Protein Z levels were assessed in plasma of all neonates by ELISA. Results: There was statistically significant decrease in Plasma Protein Z level among patients than controls. In addition, a significant decrease in PZ was present with increasing the severity of the disease. There was a significant decrease in PZ among died than survived patients. A significant positive correlation was observed between PZ level and gestational age while a significant negative correlation was observed between PZ and (severity, down score). Conclusion: Plasma Protein Z. level is decreased in neonatal respiratory distress syndrome and it may be a good biomarker for detection of the severity and prognosis of the disease. | ||||
| Keywords | ||||
| Plasma Protein Z; Respiratory Distress Syndrome; severity | ||||
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