Adherence to Sulfonylureas in Comparison to Metformin among T2DM Patients: A Systematic Review and Meta-Analysis
Alanazi, F., Alqubali, H., Alatawi, O., Alrefaei, A., Alshaikhi, A., Albalawi, M., Alwadai, A. (2022). Adherence to Sulfonylureas in Comparison to Metformin among T2DM Patients: A Systematic Review and Meta-Analysis. EKB Journal Management System, 88(1), 3900-3905. doi: 10.21608/ejhm.2022.252829
Fahad Saud Alanazi; Hind Fahad Alqubali; Omar Atallalh Alatawi; Ahmed Yassin Alrefaei; Ahmed Hussain Alshaikhi; Maha Salim Albalawi; Abdulrhman Nasser Alwadai. "Adherence to Sulfonylureas in Comparison to Metformin among T2DM Patients: A Systematic Review and Meta-Analysis". EKB Journal Management System, 88, 1, 2022, 3900-3905. doi: 10.21608/ejhm.2022.252829
Alanazi, F., Alqubali, H., Alatawi, O., Alrefaei, A., Alshaikhi, A., Albalawi, M., Alwadai, A. (2022). 'Adherence to Sulfonylureas in Comparison to Metformin among T2DM Patients: A Systematic Review and Meta-Analysis', EKB Journal Management System, 88(1), pp. 3900-3905. doi: 10.21608/ejhm.2022.252829
Alanazi, F., Alqubali, H., Alatawi, O., Alrefaei, A., Alshaikhi, A., Albalawi, M., Alwadai, A. Adherence to Sulfonylureas in Comparison to Metformin among T2DM Patients: A Systematic Review and Meta-Analysis. EKB Journal Management System, 2022; 88(1): 3900-3905. doi: 10.21608/ejhm.2022.252829

Adherence to Sulfonylureas in Comparison to Metformin among T2DM Patients: A Systematic Review and Meta-Analysis

The Egyptian Journal of Hospital Medicine
Article 262, Volume 88, Issue 1, July 2022, Page 3900-3905  XML PDF (479.46 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2022.252829
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Authors
Fahad Saud Alanazi email ; Hind Fahad Alqubali; Omar Atallalh Alatawi; Ahmed Yassin Alrefaei; Ahmed Hussain Alshaikhi; Maha Salim Albalawi; Abdulrhman Nasser Alwadai
Abstract
Background: Improved adherence to oral anti-hyperglycemic drugs (OAHs) may improve glucose control while also lowering diabetes morbidity, mortality, and long-term health resource consumption. Aim: This study aims to compare the adherence of type 2 diabetes mellitus (T2DM) patients to sulfonylureas with metformin.
Methods: This systematic review and meta-analysis followed the PRISMA 2020 guidelines. A systematic search was done in PubMed, MEDLINE through Clarivate, Web of Science through Clarivate, and EBSCO. Studies retrieved were managed in Rayyan–Intelligent systematic reviews website for duplicate removal and screening. Review Manager 5.4 was used to generate forest plots to estimate pooled odds ratios using a random-effect model. We used the Higgin’s I2 test for assessing between-study heterogeneity. We used funnel plots for assessment of publication bias.
Results: This review included data from 11 studies on 274,202 T2DM patients. Random effect meta-analysis revealed that the odds for higher proportion of adherence favoured sulfonylurea group (OR = 1.34, 95% CI [1.08-1.65]). The comparison between sulfonylurea and metformin adherence using OR was significant (p=0.007).
 Conclusion: The study concludes that T2DM patients were significantly more adherent to sulfonylurea than metformin, however, the analysis showed significant heterogeneity. We recommend adherence measures to be devised when prescribing OHAs.
 
Keywords
Adherence; Metformin; Sulfonylurea; T2DM
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