Predicting causes of death among vulvar cancer patients; SEER database analysis
Hafez, M., Tawfik, G., Yousef, R., Antar, S., Nazzal, A., Hosh, M., Warda, M., Leu, R., Refky, B. (2022). Predicting causes of death among vulvar cancer patients; SEER database analysis. EKB Journal Management System, 6(2), 31-40. doi: 10.21608/jcbr.2022.115165.1242
Mohamed Tarek Hafez; Gehad Tawfik; Reem Yousef; Sarah Antar Antar; Ahmed Nazzal; Mona Hosh; Mahmoud Warda; Richard Leu; Basel Refky. "Predicting causes of death among vulvar cancer patients; SEER database analysis". EKB Journal Management System, 6, 2, 2022, 31-40. doi: 10.21608/jcbr.2022.115165.1242
Hafez, M., Tawfik, G., Yousef, R., Antar, S., Nazzal, A., Hosh, M., Warda, M., Leu, R., Refky, B. (2022). 'Predicting causes of death among vulvar cancer patients; SEER database analysis', EKB Journal Management System, 6(2), pp. 31-40. doi: 10.21608/jcbr.2022.115165.1242
Hafez, M., Tawfik, G., Yousef, R., Antar, S., Nazzal, A., Hosh, M., Warda, M., Leu, R., Refky, B. Predicting causes of death among vulvar cancer patients; SEER database analysis. EKB Journal Management System, 2022; 6(2): 31-40. doi: 10.21608/jcbr.2022.115165.1242

Predicting causes of death among vulvar cancer patients; SEER database analysis

Egyptian Journal of Cancer and Biomedical Research
Article 4, Volume 6, Issue 2, June 2022, Page 31-40  XML PDF (1.45 MB)
Document Type: Original Article
DOI: 10.21608/jcbr.2022.115165.1242
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Authors
Mohamed Tarek Hafez email orcid 1; Gehad Tawfik2; Reem Yousef2; Sarah Antar Antar2; Ahmed Nazzal2; Mona Hosh2; Mahmoud Warda2; Richard Leu3; Basel Refky4
1ONCOLOGY CENTER MANSOURA UNIVERSITY
2Mansoura University Faculty of Medicine
3Cosmic Lens Consulting, LLC, USA
4Oncology Center Mansoura University
Abstract
Background: This study aims to identify causes of death among vulvar cancer patients diagnosed in the period between 2004 and 2013, using the Surveillance, Epidemiology, and End-Results (SEER) Program. Patients Methods: Data of 3769 Women with vulvar cancer, aged 40 years or more were extracted. Causes of death were categorized into vulvar cancer death, other cancer death, and other causes of death. The statistical analysis was performed using R (Version 3.4.0) utilizing the survival package (Version 2.41-3) and competing for the risk package. Results: At the end of the follow-up period, 2520 patients (66.9%) were alive while 1249 patients (33.14%) were dead. Of the 1249 deaths, 632 (50.6%) were attributed to vulvar cancer, 184 (14.7%) to other cancers, and 433 (34.66%) to other causes of death. Cardiovascular diseases and other gynecological cancers were the most common causes of death after vulvar cancer representing 16.65% and 5.28% of all deaths respectively. Advanced disease stage and more than three positive lymph nodes were associated with an increased risk of death due to other cancers. Simple and total surgeries were associated with lower risk. Non-cancer-related deaths were higher in unmarried women or in those who underwent surgical treatment. Conclusions: Non-cancer causes in addition to cancers other than vulvar cancer account for half of all deaths that occurred among patients diagnosed with vulvar cancer. Cardiovascular diseases and other gynecologic cancers are the most significant causes of death after vulvar cancer. 
Keywords
Vulvar cancer; Competing Mortality; Causes of death; SEER database
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