Zinc(II) complexes derived from ibuprofen Schiff base ligands: synthesis, characterization and biological activity
el-Hameed, M., Abdel-Rahman, L., Abdel-Mawgoud, A., Mohamed, S. (2022). Zinc(II) complexes derived from ibuprofen Schiff base ligands: synthesis, characterization and biological activity. EKB Journal Management System, 7(3), 123-130. doi: 10.21608/sjsci.2022.151732.1013
Mohamed Abd el-Hameed; Laila H. Abdel-Rahman; Abdel-Mawgoud M. Abdel-Mawgoud; Shaaban K. Mohamed. "Zinc(II) complexes derived from ibuprofen Schiff base ligands: synthesis, characterization and biological activity". EKB Journal Management System, 7, 3, 2022, 123-130. doi: 10.21608/sjsci.2022.151732.1013
el-Hameed, M., Abdel-Rahman, L., Abdel-Mawgoud, A., Mohamed, S. (2022). 'Zinc(II) complexes derived from ibuprofen Schiff base ligands: synthesis, characterization and biological activity', EKB Journal Management System, 7(3), pp. 123-130. doi: 10.21608/sjsci.2022.151732.1013
el-Hameed, M., Abdel-Rahman, L., Abdel-Mawgoud, A., Mohamed, S. Zinc(II) complexes derived from ibuprofen Schiff base ligands: synthesis, characterization and biological activity. EKB Journal Management System, 2022; 7(3): 123-130. doi: 10.21608/sjsci.2022.151732.1013

Zinc(II) complexes derived from ibuprofen Schiff base ligands: synthesis, characterization and biological activity

Sohag Journal of Sciences
Volume 7, Issue 3, September 2022, Page 123-130  XML PDF (1.21 MB)
Document Type: Regular Articles
DOI: 10.21608/sjsci.2022.151732.1013
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Authors
Mohamed Abd el-Hameed email orcid 1; Laila H. Abdel-Rahmanorcid 2; Abdel-Mawgoud M. Abdel-Mawgoudorcid 2; Shaaban K. Mohamedorcid 3
1Chemistry Department, Faculty of Science, Sohag University, 82534 Sohag, Egypt
2Chemistry Department, Faculty of Science, Sohag University, Sohag, Egypt
3Chemistry and Environmental Division, Manchester Metropolitan University, Manchester M1 6GD, England
Abstract
The produced Ibuprofen derivative, Ibuprofen hydrazide and 2-hydroxy-1-naphthaldhyde to form HL1 and Ibuprofen hydrazide and 5-bromosalicylaldehyde to form HL2 ligand, was reacted with Zn(II) ions complexes under experimental conditions to produce the ZnL1 and ZnL2complexes. The ligands and their complexes were characterised using elemental analyses(C,H,N), FT-IR, electronic spectra, magnetic moments, molar ratio measurements, and molar conductance tests. The in-vitro cytotoxic activity of the new ligand and their complexes was also investigated against colon cancer cells (HCT-116 cell line), breast cancer cells (MCF-7 cell line), and hepatic cancer cells (MCF-8 cell line). Ibuprofen Schiff base ligands and their complexes wer tested in-vitro against bacterial pathogens and fungi. Synthetic compounds and the conventional antibiotic Gentamycin were tested in vitro against two Gram positive bacteria (S. aureus and B. subtilis) and two Gram negative bacteria (E. coli and P. vulgaris). In vitro antifungal potency, the new Schiff base ligands and their complexes were tested against two fungus, C. albicans and A. fumigatus, and compared to Ketoconazole, a common antifungal drug.
Keywords
Schiff base; Zn complexes; Ibuprofen; anti-bacterial
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