The Potential Hepatic and Renal Toxic Effects of Sodium Glutamate and Sulfite Sodium in Broiler Chickens
Elsharkawy, E., Abd Elghaffar, S., Abd Ellatief, E., Elzoghby, R., Abdel-Maguid, D. (2022). The Potential Hepatic and Renal Toxic Effects of Sodium Glutamate and Sulfite Sodium in Broiler Chickens. EKB Journal Management System, 2(2), 10-16. doi: 10.21608/nvvj.2022.141817.1006
Eman E. Elsharkawy; Sary K. Abd Elghaffar; Eman M. Abd Ellatief; Rabab R. Elzoghby; Doaa S. Abdel-Maguid. "The Potential Hepatic and Renal Toxic Effects of Sodium Glutamate and Sulfite Sodium in Broiler Chickens". EKB Journal Management System, 2, 2, 2022, 10-16. doi: 10.21608/nvvj.2022.141817.1006
Elsharkawy, E., Abd Elghaffar, S., Abd Ellatief, E., Elzoghby, R., Abdel-Maguid, D. (2022). 'The Potential Hepatic and Renal Toxic Effects of Sodium Glutamate and Sulfite Sodium in Broiler Chickens', EKB Journal Management System, 2(2), pp. 10-16. doi: 10.21608/nvvj.2022.141817.1006
Elsharkawy, E., Abd Elghaffar, S., Abd Ellatief, E., Elzoghby, R., Abdel-Maguid, D. The Potential Hepatic and Renal Toxic Effects of Sodium Glutamate and Sulfite Sodium in Broiler Chickens. EKB Journal Management System, 2022; 2(2): 10-16. doi: 10.21608/nvvj.2022.141817.1006

The Potential Hepatic and Renal Toxic Effects of Sodium Glutamate and Sulfite Sodium in Broiler Chickens

New Valley Veterinary Journal
Article 2, Volume 2, Issue 2, June 2022, Page 10-16  XML PDF (528.9 K)
Document Type: Original Article
DOI: 10.21608/nvvj.2022.141817.1006
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Authors
Eman E. Elsharkawy1; Sary K. Abd Elghaffar2; Eman M. Abd Ellatief3; Rabab R. Elzoghby4; Doaa S. Abdel-Maguid email 5
1Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt.
2Department of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt.
3Veterinarian at Assiut university hospitals.
4Department of Pharmacology, Faculty of Veterinary Medicine, New Valley University, New Valley, Egypt.
5Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, New Valley University, New Valley, Egypt
Abstract
Monosodium glutamate (MSG) and sulfite are frequently used as flavor enhancer and most applied as food additives in modern nutrition globally. This study planned to investigate the potential toxic effect of MSG on liver and kidney when administered to broiler chickens during the growth period. Forty, day-old, unsexed Ross broiler chicks, they assigned into 4 groups: 10 chicks each, fed on standard diet mixed with 0.75g of MSG/kg (group A), sodium metabisulfite 3.5/kg (group B), 0.75 g MSG + 3.5g sulfite /kg (group C) and control group (group D). Oxidative stress indicators assay such as malondialdehyde (MDA), and superoxide dismutase (SOD), activities were determined. Liver and kidney function testes foe alp enzyme and creatinine metabolite were examined. Histo- architecture of liver and kidney tissues were conducted in all exposed groups. The results indicated that the increase in the determination levels of serum ALP, creatinine, MDA and SOD in all exposed groups in comparison with control. Disturbance in hepatic architecture with hydropic changes in hepatic cells with congestion of the interstitial blood vessels and necrobiosis of renal tubular epithelium.
Keywords
Monosodium glutamate; metabisulfite; oxidative stress SOD; lipid peroxides; broiler
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