The Rationale of Gingerol as a Main Phenolic Compound of Zingiber in Improving Hepatocellular Carcinoma Induced by Dimethylaminoazobenzene: Scientific Implication
Anbar, E., El-Naggar, S., Salama, A. (2022). The Rationale of Gingerol as a Main Phenolic Compound of Zingiber in Improving Hepatocellular Carcinoma Induced by Dimethylaminoazobenzene: Scientific Implication. EKB Journal Management System, 14(2), 25-30. doi: 10.21608/eajbsd.2022.254286
Esraa Ali Anbar; Sabry Ali El-Naggar; Afrah Fatthi Salama. "The Rationale of Gingerol as a Main Phenolic Compound of Zingiber in Improving Hepatocellular Carcinoma Induced by Dimethylaminoazobenzene: Scientific Implication". EKB Journal Management System, 14, 2, 2022, 25-30. doi: 10.21608/eajbsd.2022.254286
Anbar, E., El-Naggar, S., Salama, A. (2022). 'The Rationale of Gingerol as a Main Phenolic Compound of Zingiber in Improving Hepatocellular Carcinoma Induced by Dimethylaminoazobenzene: Scientific Implication', EKB Journal Management System, 14(2), pp. 25-30. doi: 10.21608/eajbsd.2022.254286
Anbar, E., El-Naggar, S., Salama, A. The Rationale of Gingerol as a Main Phenolic Compound of Zingiber in Improving Hepatocellular Carcinoma Induced by Dimethylaminoazobenzene: Scientific Implication. EKB Journal Management System, 2022; 14(2): 25-30. doi: 10.21608/eajbsd.2022.254286

The Rationale of Gingerol as a Main Phenolic Compound of Zingiber in Improving Hepatocellular Carcinoma Induced by Dimethylaminoazobenzene: Scientific Implication

Egyptian Academic Journal of Biological Sciences, D. Histology & Histochemistry
Article 3, Volume 14, Issue 2, December 2022, Page 25-30  XML PDF (521.99 K)
Document Type: Original Article
DOI: 10.21608/eajbsd.2022.254286
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Authors
Esraa Ali Anbar1; Sabry Ali El-Naggar2; Afrah Fatthi Salama3
1Division of Biochemistry, Department of Chemistry, Faculty of Science, Tanta University, Egypt.
2Physiology Department, Faculty of Science, Tanta University, Tanta, Egypt.
3Division of Biochemistry, Department of Chemistry, Faculty of Science, Tanta University, Egypt
Abstract
Among different types of cancers, hepatocellular carcinoma (HCC) is widely distributed and considered to be the fifth leading cause of death around the world. Although the presence of different treatment choices with liver transplantation and liver excision is at the top of the list, there is a high need for more investigations to be done to figure out variant options with higher efficacy and lower cost. Inflammation and oxidative stress are very common factors in cancer biology that play a substantial role in cancer development and progression. These deep understandings resulted in exploring the branch of phytochemistry to help find effective natural products and their derivatives. Among hundreds of phytochemical choices, gingerol is known for its powerful antioxidant and anti-inflammatory activities positioning it to be a very promising compound added to the list of cancer treatment options. Besides these activities, gingerol was documented to have anti-cancer effects as it arrests the cell cycle as well as induces apoptosis. In our study design, the therapeutic potential of gingerol was evaluated in an animal model. The conclusion that confirms our hypothesis is hoped to have a distinct role in developing cancer therapies.
Keywords
Gingerol; Liver; Cancer; Chemotherapy; Phenobarbital; Dimethylaminoazobenzene
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