Possible Protective Effects of Mirabegron on Experimentally Induced Non-alcoholic Steatohepatitis in Rats
Makar, N., Abdullah, O., Abu-Raia, N., abdel aziz, E., elsayed, A. (2022). Possible Protective Effects of Mirabegron on Experimentally Induced Non-alcoholic Steatohepatitis in Rats. EKB Journal Management System, 39(Special issue (Academic)), 277-293. doi: 10.21608/bmfj.2022.100055.1496
Nasr Nazmy Makar; Omaima Mohamed Abdullah; Nashwa Hassan Abu-Raia; Eman Abdelmohsen abdel aziz; alzahraa zakarya elsayed. "Possible Protective Effects of Mirabegron on Experimentally Induced Non-alcoholic Steatohepatitis in Rats". EKB Journal Management System, 39, Special issue (Academic), 2022, 277-293. doi: 10.21608/bmfj.2022.100055.1496
Makar, N., Abdullah, O., Abu-Raia, N., abdel aziz, E., elsayed, A. (2022). 'Possible Protective Effects of Mirabegron on Experimentally Induced Non-alcoholic Steatohepatitis in Rats', EKB Journal Management System, 39(Special issue (Academic)), pp. 277-293. doi: 10.21608/bmfj.2022.100055.1496
Makar, N., Abdullah, O., Abu-Raia, N., abdel aziz, E., elsayed, A. Possible Protective Effects of Mirabegron on Experimentally Induced Non-alcoholic Steatohepatitis in Rats. EKB Journal Management System, 2022; 39(Special issue (Academic)): 277-293. doi: 10.21608/bmfj.2022.100055.1496

Possible Protective Effects of Mirabegron on Experimentally Induced Non-alcoholic Steatohepatitis in Rats

Benha Medical Journal
Article 287, Volume 39, Special issue (Academic), September and October 2022, Page 277-293  XML PDF (1.11 MB)
Document Type: Original Article
DOI: 10.21608/bmfj.2022.100055.1496
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Authors
Nasr Nazmy Makar1; Omaima Mohamed Abdullah2; Nashwa Hassan Abu-Raia3; Eman Abdelmohsen abdel aziz4; alzahraa zakarya elsayed email 5
1phamacology department,bana faculty of medicine
2Pharmacology departement Faculty of medicine, Benha university
3Clinical Pharmacology, Faculty of medicine, Benha university
4pharmacology department, Faculty of medicine, benha university
5pharmacology department,faculty off medicine,banha university
Abstract
Background: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. Mirabegron is a novel, once-daily orally active, first-in-class, potent β3-adrenoreceptor (AR) agonist. Aim of the study: This work aimed at exploring the possible prophylactic effect of mirabegron on non-alcoholic steatohepatitis (NASH) induced experimentally by high fat diet in rats. Material and methods: Rats were divided into 5 groups: Control normal group, Mirabegron group, Untreated NASH group (received a high fat diet for 12 weeks), Low dose mirabegron pre-treated NASH group (treated with mirabegron 5 mg/kg/day orally for 12 weeks) and High dose mirabegron pre-treated NASH group (treated with mirabegron 10 mg/kg/day orally for 12 weeks). Results: Mirabegron produced significant reduction of liver enzymes, total cholesterol, triglycerides and Low-density lipoprotein cholesterol (LDL-c) and significant elevation of high- density lipoprotein-cholesterol (HDL-c),the serum level of glycosylated hemoglobin (HbA1c), fasting glucose and insulin levels were significantly decreased with significant improvement of insulin sensitivity observed by lowering of insulin resistance index (HOMA-IR), serum adiponectin level also showed significant elevation. These results were supported by marked improvement of liver histopathology compared to non-treated group, with the best results obtained by using the high dose of mirabegron.
Conclusions: These data suggest that mirabegron may have a potential usefulness in the prevention of NASH as regard to liver enzymes, lipid profile, serum HbA1c, fasting insulin and blood glucose, insulin resistance index, and serum adiponectin levels with improvement of liver histopathological changes.
Keywords
NAFLD; HFD; Mirabegron
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