Therapeutic potential of Bee gomogenat against testicular damage in a streptozotocin- induced type I diabetic mouse model
Sayed, L., Mohamed, H., Khaleel Abd Elghaffar, S., Badr, G. (2022). Therapeutic potential of Bee gomogenat against testicular damage in a streptozotocin- induced type I diabetic mouse model. EKB Journal Management System, 1(1), 17-37. doi: 10.21608/aunj.2022.134540.1008
leila Hassan Sayed; Hossam El Din Mohamed; Sary Khaleel Abd Elghaffar; Gamal Badr. "Therapeutic potential of Bee gomogenat against testicular damage in a streptozotocin- induced type I diabetic mouse model". EKB Journal Management System, 1, 1, 2022, 17-37. doi: 10.21608/aunj.2022.134540.1008
Sayed, L., Mohamed, H., Khaleel Abd Elghaffar, S., Badr, G. (2022). 'Therapeutic potential of Bee gomogenat against testicular damage in a streptozotocin- induced type I diabetic mouse model', EKB Journal Management System, 1(1), pp. 17-37. doi: 10.21608/aunj.2022.134540.1008
Sayed, L., Mohamed, H., Khaleel Abd Elghaffar, S., Badr, G. Therapeutic potential of Bee gomogenat against testicular damage in a streptozotocin- induced type I diabetic mouse model. EKB Journal Management System, 2022; 1(1): 17-37. doi: 10.21608/aunj.2022.134540.1008

Therapeutic potential of Bee gomogenat against testicular damage in a streptozotocin- induced type I diabetic mouse model

Assiut University Journal of Multidisciplinary Scientific Research
Volume 1, Issue 1, 2022, Page 17-37  XML PDF (972.2 K)
Document Type: Novel Research Articles
DOI: 10.21608/aunj.2022.134540.1008
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Authors
leila Hassan Sayed email orcid 1; Hossam El Din Mohamed1; Sary Khaleel Abd Elghaffarorcid 2; Gamal Badrorcid 3
1Zoology Department, Faculty of Science, Assiut University
2Pathology and clinical pathology Department, Faculty of Veterinary Medicine, Assiut University
3Professor of Immunology Zoology Department, Faculty of Science, Assiut University, 71516 Assiut, Egypt
Abstract
Diabetes Mellitus (DM) is a metabolic disorder that has serious effects for male fertility. Additionally, DM mediates impairment of spermatogenesis; decrease in count of sperm, viability, and motility; and apoptosis in both somatic and germ cells. Our study aimed to investigate the dietary effect of bee gomogenat (BG) supplementation on the architecture of testis in mouse model of streptozotocin (STZ)-induced type 1 diabetes (TID). We used three animal groups: control non-diabetic, diabetic, and BG-treated diabetic mice. STZ-induced diabetes was associated with pathological alterations in the architecture of the testis, decreased distribution of YAP+ Leydig cells in testis sections and decreased level of testosterone. Furthermore, diabetic mice showed perturbed alteration in the expression of PPAR-γ, Nrf2 and 3β-HSD in testis as compared to control animals. Interestingly, supplementation of diabetic mice with BG mediated an improvement the architecture of testis, restored the distribution of YAP+ Leydig cells and the testosterone level. Furthermore, Treatment of diabetic mice with BG significantly restored the expression levels of PPAR-γ, Nrf2 and 3β-HSD nearly to control animals.
Conclusion: Our data revealed, for the first time, the beneficial impacts of BG supplementation on the architecture and functions of testis during T1D.
Keywords
Bee gomogenat; diabetes mellitus; testis; testosterone; Leydig cell
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