Radiographic and Histopathologic Evaluation of L-Carnitine and Vitamin E Efficacy on Irradiated Jaw Bones | ||||
Egyptian Journal of Radiation Sciences and Applications | ||||
Article 13, Volume 31, Issue 2, December 2018, Page 215-224 PDF (792.26 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/ejrsa.2019.3684.1057 | ||||
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Authors | ||||
Amira Sayed1; Osama El-Shall2; Dina El Husseiny1; Mai Attia2; Salwa Ahmed 1 | ||||
1Health Radiation Research Department, National Center for Radiation Research and Technology (NCRRT), Atomic Energy Authority (AEA), Cairo, Egypt | ||||
2Oral Medicine, Periodontology, Oral Diagnosis and Radiology Department, Faculty of Dental Medicine for Girls, Al-Azhar University, Cairo, Egypt | ||||
Abstract | ||||
The aim of this study is to evaluate the efficacy of L-Carnitine and vitamin E alone or in combination on irradiated jaw bones in rats through radiographic assessment of the bone density and histopathologic examination of bone morphology. Forty male albino rats were divided randomly into 4 groups each of 10 rats. Group R represented the rats that received fractionated radiation dose (2 Gray per fraction) for one week. Groups LR, ER and LER represented the rats that received L-Carnitine 300mg/kg via intra peritoneal injection, vitamin E 40mg/kg via intramuscular injection or both daily for five days and then exposed to fractionated radiation 2 Gray day after day for one week after the last treatment, respectively. Data revealed a significant improvement of mandibular bone density in the groups received L-Carnitine, vitamin E alone or in combination as compared to the gamma-irradiated group. Moreover, the treated groups showed almost normal morphology of both mandibular bone and periodontal ligament in contrast to the gamma irradiated group where bone resorption and periodontal ligament degeneration and vacuolization were detected. In conclusion, gamma radiation had a deleterious effect on mandibular bone and periodontal ligament as indicated by decreased bone density and altered morphology. In addition, L-Carnitine and vitamin E treatment alone or in combination could, to a large extent, maintain the normal bone density and preserve the morphological architecture of mandibular bone and periodontal ligament. | ||||
Keywords | ||||
Gamma Irradiation; Vitamin E; L-carnitine; Mandible; periodontal ligament; bone density | ||||
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