Study of the Midkine level and its Correlation with toxic and Essential Metals in Patients with Atherosclerosis | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 66, Issue 5, May 2023, Page 161-167 PDF (290.68 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2022.148718.6427 | ||||
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| Authors | ||||
| Obeda A. Al-Kado1; Luay A. Al-Helaly* 2 | ||||
| 1Directorate of Education in Nineveh /Mosul, Iraq | ||||
| 2Chemistry department, College of science, University of Mosul, Mosul, Iraq | ||||
| Abstract | ||||
| Abstract The research includes studying of level for midkine (MK), toxic metals (TMs) (Including: Arsenic(As), Mercury(Hg), Cadmium(Cd)) and essential metals (EMs) (Including: Magnesium(Mg), Calcium (Ca), Iron(Fe)) in serum for atherosclerosis patients (APs). The study was done in Mosul city on (107) samples, including 57 for APs and 50 who were healthy as a control group. The results showed a significant increase in MK, As, Hg and Cd levels for all studied (All, males and females) groups compared with control groups. While, the results of measurements of EMs indicated that there was a significant decrease in Ca, Mg and Fe compared with control groups and this indicates the effect of atherosclerosis. The study indicated that the MK increased in patients with atherosclerosis, and it increased in males more than in female patients, in addition, to increase in TMs measured (As, Hg and Cd) helped increase the pathogenesis of atherosclerosis by increasing the level of MK and decreasing levels of Ca, Mg and Fe. Thus, increasing the intake of nutritional supplements from essential minerals is important in reducing the severity of infection. And that MK can be considered a good indicator of the occurrence of atherosclerosis. | ||||
| Keywords | ||||
| Keywords: Atherosclerosis; Midkine; Arsenic; Mercury; Cadmium; Essential metals | ||||
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